Dendritic and Hybrid Linear-Globular Molecules: Design and Synthetic Approaches

树枝状和混合线性球状分子：设计和合成方法

• 批准号: 9816166
• 负责人: Jean M. J. Frechet
• 金额: $ 39.6万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9816166&HistoricalAwards=false
• 关键词: Dendritic; Hybrid; Linear; Globular; Molecules

9816166FrechetThe last decade has seen an explosion in research, both pure and applied, exphasizing molecular architecture, supramolecular chemistry, and chemistry at the nanometer scale. Dendrimers and other dendritic molecules such as linear-dendritic hybrids and hyperbranched polymers have been major contributors to this surge of activity spanning several fields including chemistry, materials science, physics, medicine, and mathematics.This project is focused on the discovery and development of versatile families of dendritic polymers, the establishment of reliable synthetic methods and procedures for their preparation, and their early characterization. One of its aims is to stimulate the development of novel applications by providing access to versatile structures and contributing to a better fundamental understanding of these unique molecules and their behavior. %%% Synthetic targets include both simplified and high yielding approaches to dendritic molecules, the use of more accessible starting materials, as well as the design and preparation of more complex targets for which structure defines function. For example, the exploration of a versatile new family of hydrolytically stable dendrimers with reactive end-groups is proposed. These dendrimers, obtained in high yield processes from simple starting materials, will complement the limited array of dendrimer families in widespread use today. Their potential applications span a broad spectrum from targeted drug delivery, to sensors, molecular "machines", micellar catalysts, nanoscale components, or biological mimics. Hyperbranched polymers, obtained through polymerization processes rather than repetitive stepwise syntheses, are candidates for use in industrial additives, improved plastics, coatings, or adhesives. Finally, well-defined linear hybrid-dendritic structures should prove useful as building blocks in supramolecular chemistry, surface active agents, micellar catalysts, adsorbents, etc. The characterization and availability of these novel globular molecules will also contribute greatly to our understanding of structure-property relationships.

9816166 Frechet在过去的十年里，无论是纯的还是应用的研究都出现了爆炸式的增长，包括分子结构、超分子化学和纳米尺度的化学。 树枝状聚合物和其他树枝状分子，如线性-树枝状杂化物和超支化聚合物，是这一活动激增的主要贡献者，跨越了化学、材料科学、物理、医学和数学等多个领域。本项目的重点是发现和开发多功能树枝状聚合物家族，建立可靠的合成方法和制备程序，以及它们的早期表征。 其目标之一是通过提供对多功能结构的访问，促进对这些独特分子及其行为的更好的基本理解，来刺激新应用的开发。 %%% 合成靶标包括树突状分子的简化和高产方法，使用更容易获得的起始材料，以及设计和制备结构定义功能的更复杂的靶标。 例如，探索一个通用的新的家庭水解稳定的树枝状聚合物与反应性端基提出。 这些树枝状聚合物，从简单的起始材料在高产率的过程中获得，将补充有限的阵列的树枝状聚合物家族在今天广泛使用。它们的潜在应用范围很广，从靶向药物递送到传感器、分子“机器”、胶束催化剂、纳米级组分或生物模拟物。 超支化聚合物通过聚合过程而不是重复的逐步合成获得，是用于工业添加剂、改进的塑料、涂料或粘合剂的候选物。 最后，定义良好的线性混合树枝状结构应证明有用的积木在超分子化学，表面活性剂，胶束催化剂，吸附剂等这些新的球状分子的表征和可用性也将大大有助于我们理解的结构-性能关系。