Studies in Aziridine-Allylsilane Cyclizations

Bergmeier教授的研究探索了烯丙基硅烷和氮丙啶分子内反应所带来的环化反应。 反应将产生碳环高烯丙基胺或稠合双环吡咯烷，这取决于所选择的条件。 进一步的研究将确定反应中立体选择性的程度，并确定可以改变以控制其立体化学的那些因素。 形式[3+2]环化反应将被扩展，以提供制备多个多环分子的方法。最后，天然产物的合成将进行，这可能是有利的，因为他们是建立合成方法的实用性，因为他们是refined.With这个奖项，有机和大分子化学计划支持斯蒂芬C教授的研究。俄亥俄州州立大学的Bergmeier说。 Bergmeier教授研究化学反应，使不同的分子从一个单一的前体创建。 各种各样的天然化合物以及合成药物分子已被确定为伯格迈尔的化学将提供容易的访问。

Professor Bergmeier's research explores cyclization reactions brought about by the intramolecular reaction of an allylsilane and an aziridine. The reaction will yield either a carbocyclic homoallylic amine or a fused bicyclic pyrrolidine, depending on the conditions that are selected. Further study will determine the extent of stereoselectivity in the reaction and identify those factors that can be altered to control its stereochemistry. The formal [3+2] cyclization will be expanded upon to provide the means of preparing multiple polycyclic molecules. Finally, natural product synthesis will be undertaken where it may be advantageous to establish the utility of the synthetic methods as they are refined.With this award, the Organic and Macromolecular Chemistry Program supports the research of Professor Stephen C. Bergmeier of the Ohio State University. Professor Bergmeier studies chemical reactions that enable the creation of different molecules from a single precursor. A wide variety of naturally occuring compounds as well as synthetic pharmaceutical molecules have been identified for which Bergmeier's chemistry would provide easy access.