The copolymerization of carbon dioxide and aziridine for the preparation of aliphatic polyurethanes

二氧化碳与氮丙啶共聚制备脂肪族聚氨酯

• 批准号: DDG-2015-00025
• 负责人: Scott, Jennifer
• 金额: $ 0.73万
• 依托单位: Royal Military College of Canada
• 依托单位国家: 加拿大
• 项目类别: Discovery Development Grant
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=612429
• 关键词: copolymerization; carbon; dioxide; aziridine; preparation

Despite the growth and application of sterilization procedures at hospitals and medical clinics, medical devices and implants are still the cause of millions of hospital-acquired bacterial infections each year. As such, the development of self-sterilizing materials has grown in recent years. The dangers associated with hospital-based bacterial infections are compounded by the increased occurrence of "super bugs", bacteria that have developed a resistance to many of our established antibacterial agents. In the past 25 years, oxazolidinones have emerged as one of the greatest and most promising new developments in the area of antibiotics. This proposal highlights a method to prepared a class of polyurethane materials that have the ability to degrade into oxazolidinone antibacterial molecules. The proposal focuses on the polymerization method and characterization of the resulting novel materials. In addition, the process also involves the incorporation of carbon dioxide as a molecular building block into the polymers framework. The ability to use waste carbon dioxide as a source of C in the preparation of materials is extremely exciting in the development of environmentally sustainable chemistry practices and has tremendous implications for our abilities to address global warming.

尽管在医院和医疗诊所中灭菌程序的增长和应用，但医疗设备和植入物仍然是每年数百万医院获得性细菌感染的原因。因此，近年来，自消毒材料的开发已经增长。与医院细菌感染相关的危险因“超级细菌”的增加而加剧，这些细菌对我们的许多既定抗菌剂产生了耐药性。在过去的25年里，恶唑烷酮类药物已经成为抗生素领域最伟大和最有前途的新进展之一。该提案强调了制备一类具有降解为恶唑烷酮抗菌分子能力的聚氨酯材料的方法。该提案的重点是聚合方法和所得新材料的表征。此外，该方法还涉及将二氧化碳作为分子构建块并入聚合物框架中。在材料制备中使用废二氧化碳作为C源的能力在环境可持续化学实践的发展中是非常令人兴奋的，并且对我们解决全球变暖的能力具有巨大的影响。