The copolymerization of carbon dioxide and aziridine for the preparation of aliphatic polyurethanes

尽管消毒程序在医院和医疗诊所得到了发展和应用，但医疗器械和植入物仍然是每年数百万医院获得性细菌感染的原因。因此，自消毒材料的发展在最近几年得到了发展。与医院细菌感染相关的危险因“超级细菌”的增加而复杂化，“超级细菌”是一种对我们许多现有抗菌剂产生抗药性的细菌。在过去的25年里，恶唑烷酮类化合物已经成为抗生素领域最伟大和最有前途的新发展之一。这项提案强调了一种制备一类能够降解为恶唑烷酮抗菌分子的聚氨酯材料的方法。该提案的重点是聚合方法和由此产生的新材料的表征。此外，该过程还涉及将二氧化碳作为分子构建块加入到聚合物框架中。利用废弃二氧化碳作为材料制备中碳的来源的能力在环境可持续化学实践的发展中非常令人兴奋，并对我们应对全球变暖的能力具有巨大的影响。

Despite the growth and application of sterilization procedures at hospitals and medical clinics, medical devices and implants are still the cause of millions of hospital-acquired bacterial infections each year. As such, the development of self-sterilizing materials has grown in recent years. The dangers associated with hospital-based bacterial infections are compounded by the increased occurrence of "super bugs", bacteria that have developed a resistance to many of our established antibacterial agents. In the past 25 years, oxazolidinones have emerged as one of the greatest and most promising new developments in the area of antibiotics. This proposal highlights a method to prepared a class of polyurethane materials that have the ability to degrade into oxazolidinone antibacterial molecules. The proposal focuses on the polymerization method and characterization of the resulting novel materials. In addition, the process also involves the incorporation of carbon dioxide as a molecular building block into the polymers framework. The ability to use waste carbon dioxide as a source of C in the preparation of materials is extremely exciting in the development of environmentally sustainable chemistry practices and has tremendous implications for our abilities to address global warming.