吲哚类生物碱Minfiensine所含的基本骨架和独特的多环体系吸引了众多合成化学家的兴趣，成为孕育新的合成方法和检验合成方法在复杂分子合成中实战效果的绝佳平台。同时，由于Minfiensine及其他结构类似天然产物所含的多样的生物活性，尤其是抗癌活性，使其可以作为潜在的分子探针或者苗头/先导化合物进行化学生物学和药物化学方面的研究。本课题旨在探索针对Minfiensine的新的合成方法，以期实现对该天然产物的更简洁、实用的不对称合成；同时进行Minfiensine类似物的合成，为进行相应的化学生物学和药物化学研究打下基础。

Minfiensine, an indoline alkaloid, has received considerable attention from the synthetic community due to its unique 1,2,3,4-tetrahydro-9a,4a- (iminoethano)-9H-carbazole backbone and interconnected ring system. Since its first isolation, the natural product has become a molecular benchmark to cultimate the development of novel synthetic strategies and calibrate the utility of these approaches in complex tartget synthesis. Moreover, minfiensine and other related natural products comtaining the same tetracyclic core show diverse biological activities, particular anti-cancer activity, which render them as potential biological probes and medicinally important hits or leads. The current proposal is designed to develop a more concise and efficient strategy for the asymmetric total synthesis of minfiensine; Analogs of minfiensine will also be synthesized through diversity oriented synthesis and diverted total synthesis, and thus provide molecules for chemical biology and medicinal chemistry research.