Purchase of Circular Dichroism Spectrometer for Research in Carcinogen-DNA Interactions

购买圆二色光谱仪用于致癌物-DNA相互作用研究

• 批准号: 9816507
• 负责人: Harmon Abrahamson
• 金额: $ 7.92万
• 依托单位: University of North Dakota Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9816507&HistoricalAwards=false
• 关键词: Purchase; Circular; Dichroism; Spectrometer; Research

This award from the Chemistry Research Instrumentation and Facilities (CRIF)/Junior Faculty Program will allow the Department of Chemistry at the University of North Dakota to purchase a circular dichroism (CD) spectrometer. This instrument will be used primarily by Mahesh Lakshman, a junior faculty member, for his research program involving the synthesis and study of chiroptical properties of glycosides; and chemical synthesis for the study of carcinogen-DNA interactions. The department also plans to incorporate CD spectrometry into the advanced organic and physical chemistry laboratory courses. Measurements of optical activity have long played an essential role in the development of organic chemistry and biochemistry. The study of circular dichroism provides important information about the electronic states or structures of individual molecules or ions. These techniques are used when studying absolute configurations of molecules, reaction mechanisms and kinetics, asymmetric or stereospecific syntheses, thermodynamic properties of dissolved species, and many other stereochemical problems.

化学研究仪器和设施（CRIF）/初级教师计划的这一奖项将允许北达科他州大学化学系购买圆二色性（CD）光谱仪。 该仪器将主要由初级教师Mahesh Lakshman用于他的研究项目，涉及苷类化合物手性性质的合成和研究;以及用于致癌物与DNA相互作用研究的化学合成。 该部门还计划将CD光谱法纳入高级有机和物理化学实验室课程。 旋光性的测量长期以来在有机化学和生物化学的发展中起着至关重要的作用。 圆二色性的研究提供了关于单个分子或离子的电子状态或结构的重要信息。 这些技术用于研究分子的绝对构型、反应机理和动力学、不对称或立体定向合成、溶解物质的热力学性质以及许多其他立体化学问题。