Purchase of a Replacement Circular Dichroism Spectrometer

该奖项由化学研究仪器和设施 （CRIF）计划将协助俄亥俄州化学系 大学升级圆二色光谱仪。的 收购将加强以下领域的化学研究：（a） 肽脱甲酰基酶：机理和抑制剂设计;（B）酶 作用机理和结构-功能关系;（c）水溶性 用于不对称催化的树枝状聚合物;（d）金属的协同结合 通过CD光谱监测的与DNA的复合物;（e）结构-功能 Fe-S蛋白和裂解肽的研究：（6）结构-功能 信号肽酶的研究1. 长期以来，光学活性的测量在以下方面发挥着重要作用： 有机化学和生物化学的发展。 研究 旋光色散（ORD）或圆二色性（CD）提供了 关于电子状态或结构的重要信息 单个分子或离子。 这些技术在学习时使用 分子的绝对构型，反应机理和动力学， 不对称或立体定向合成，热力学性质， 溶解物种和许多其他立体化学问题。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at Ohio State University to upgrade a Circular Dichroism (CD) spectrometer. The acquisition will enhance chemical research in the following areas: (a) peptide deformylase: mechanism and inhibitor design; (b) enzyme mechanisms and structure-function relationship; (c) water-soluble dendrimers for asymmetric catalysis; (d) cooperative binding of metal complexes to DNA monitored by CD spectroscopy; (e) structure-function studies of Fe-S proteins and lytic peptides; (6) structure-function studies on signal peptidase 1. Measurements of optical activity have long played an essential role in the development of organic chemistry and biochemistry. The study of optical rotatory dispersion (ORD) or circular dichroism (CD) provides important information about the electronic states or structures of individual molecules or ions. These techniques are used when studying absolute configurations of molecules, reaction mechanisms and kinetics, asymmetric or stereospecific synthesis, thermodynamic properties of dissolved species, and many other stereochemical problems.