GOALI Project: Comprehensive Model of Molecular Transport and Delivery Through the Skin

9818160 Nitsche分子通过皮肤的渗透是药物贴剂和经皮递送药物、局部施用的药物以及各种个人清洁、皮肤护理和美容产品的功能的中心现象。 更好地理解这一过程是目前生物医学进步和这些领域产品开发的最重要因素之一。 它也是安全问题和评估与皮肤接触化学品和药物有关的风险的关键。 因此，人们迫切需要能够预测不同分子如何以及以多快的速度穿过皮肤。 填补这一需要需要一个基本的研究工作，旨在了解微观细节的操作运输过程，拟议的GOALI项目将联合收割机学术和工业资源，开发一个全面的理论模型，预测皮肤渗透性，体现进步难以或不可能实现的任何类型的设置单独。 它是基于合作之间的基础学术研究人员在微观运输现象领域与证明经验，在生物学应用（约翰内斯M。Nitsche，州立大学纽约布法罗分校），和一个工业合作伙伴，提供独特的广泛的研究经验，最先进的实验能力，在皮肤运输和超微结构研究，并在改进的预测模型的强烈兴趣（杰拉尔德B。Kasting，Procter Gamble Company，迈阿密谷实验室，辛辛那提）。 该项目将产生理论和计算技术，以预测表皮屏障的基本渗透性，以及毛囊和汗管的渗透性，这些渗透性穿过表面屏障，并为更深的组织和身体的循环提供捷径。 所提出的理论的一个显着特点是物理现实主义，通过在微观尺度上组织结构和材料特性的广泛信息和实验数据的结合。 这种现实主义水平最终将使预测给定药物或化学物质在仅给定其身份的情况下穿透皮肤的速度成为可能从拟议的项目产生的渗透性模型将在某种程度上与目前使用的大多数透皮给药系统、局部应用的药物和皮肤护理产品相关，正在开发或考虑中。它也将适用于各种接触皮肤的化学品和产品的风险评估过程。

9818160 Nitsche Permeation of molecules through skin is a phenomenon central to the function of drug patches and transdermally delivered drugs, topically applied pharmaceuticals, and a variety of personal cleansing, skin-care and beauty-care products. Better understanding of this process is currently one of themost important factors underlying biomedical advancement and product development in these areas. It is also key to safety issues and the assessment of risks associated with dermal exposure to chemicals and drugs. Strong need therefore exists to be able to predict how, and how fast, different molecules get through the skin. Filling this need requires a basic research effort aimed at understanding the operative transport processes in microscopic detail.The proposed GOALI project will combine academic and industrial resources to develop a comprehensive theoretical model for predicting skin permeability, embodying advances difficult or impossible to achieve within either type of setting individually. It is based on collaboration between a basic academic researcherin the field of microscopic transport phenomena with demonstrated experience in biological applications (Johannes M. Nitsche, State University of New York at Buffalo), and an industrial partner offering uniquely extensive research experience, state-of-the-art experimental capability in skin transport and ultra-structural studies, and strong interest in improved predictive models (Gerald B. Kasting, the Procter & Gamble Company, Miami Valley Laboratories, Cincinnati). The project will produce theory and computational techniques to predict both the basic permeability properties of the epidermal barrier, and the permeability properties of hair follicles and sweat ducts, which penetrate through this surface barrier and provide a shortcut to deeper tissue and the body's circulation. A distinguishing feature of the proposed theory is physical realism, via the incorporation of extensive information and experimental data on tissue structure and material properties at the microscopic scale. This level of realism will ultimately make it possible to predict how fast a given drug or chemical will penetrate through the skin given only its identity (molecular structure) and a specification of how the application or exposure occurs.The permeability model resulting from the proposed project will be relevant in some degree to most transdermal drug delivery systems, topically applied drugs and skin-care products currently in use, under development or under contemplation. It will also be applicable to the risk assessment process for a variety ofchemicals and products that contact the skin.