Autotransporter assembly: new insights and biotechnological potential

自动转运器组装：新见解和生物技术潜力

• 批准号: FT150100452
• 负责人: Dr Denisse Leyton
• 金额: $ 52.01万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-06-20 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT150100452
• 关键词: Autotransporter; assembly; new; insights; biotechnological

The objective of this project is to improve our understanding of a fundamental biological problem: how autotransporters are assembled into cellular membranes. Autotransporters are a large family of bacterial proteins that play key roles in the pathogenesis of several infectious diseases. Currently, the precise mechanism by which disease-causing molecules are assembled into the outer membranes of bacteria and mitochondria is poorly understood. The knowledge that the project develops may inform future strategies aimed at the rational treatment of bacterial and mitochondrial diseases.

该项目的目的是提高我们对一个基本生物学问题的理解：自动转运蛋白如何组装到细胞膜中。自转运蛋白是细菌蛋白质的一个大家族，在几种感染性疾病的发病机制中起关键作用。目前，致病分子组装到细菌和线粒体的外膜中的精确机制还知之甚少。该项目开发的知识可能会为未来旨在合理治疗细菌和线粒体疾病的策略提供信息。