A Spiral Approach to Chemical Concepts Using GC/MS

使用 GC/MS 探索化学概念的螺旋方法

基本信息

批准号：
9850580
负责人：
David Forsyth
金额：
$ 3.45万
依托单位：
Northeastern University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
1998
资助国家：
美国
起止时间：
1998-07-01 至 2000-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9850580&HistoricalAwards=false
关键词：
Spiral Approach Chemical Concepts Using

项目摘要

A distinct need in modern chemistry curricula is to integrate the learning of chemical concepts with the use of modern instrumentation. The instruments can be used to teach chemical concepts and, at the same time, learning the chemical concepts makes the instruments more than magical black (or beige) boxes. A specific need in teaching organic chemistry is to have an effective laboratory approach to communicate the concepts of chemical structure, especially the concepts of constitutional isomerism and stereoisomerism. In analytical chemistry, more emphasis needs to be placed on how analyses of biologically relevant samples are carried out, and, for chemistry and honors students from other majors, how experimental protocols are developed. The objective of the present project is to teach concepts of molecular structure and methods of analysis by application of modern gas chromatography/mass spectrometry (GC/MS) instrumentation in microscale experiments using a "spiral" approach. In the spiral approach, the relation between GC/MS experiments and molecular structure is re-visited in several laboratory courses spread out over one or more years. This objective is being accomplished by introducing five new experiments using GC/MS into introductory level organic and analytical chemistry courses. The new organic experiments are innovative approaches to the concepts of empirical and molecular formulas, constitutional isomerism, and stereoisomerism. The analytical experiments are part of a new approach to introduce student-designed protocols for the analysis of biologically relevant chemical samples. The proposed experiments are significant in illustrating chemical concepts that are I ) neglected in existing laboratory manuals, 2) otherwise difficult to illustrate in microscale, or 3) relevant to students more interested in biologically related subjects that are often neglected in traditional chemistry laboratory experiments.

现代化学课程的独特需求是将化学概念的学习与现代仪器的使用相结合。这些仪器可用于教授化学概念，同时学习化学概念使仪器不仅仅是神奇的黑色（或米色）盒子。教学有机化学的特定需求是有一种有效的实验室方法来传达化学结构的概念，尤其是宪法异构主义和立体异构主义的概念。在分析化学中，需要更加重视如何进行生物学相关样本的分析，对于化学和尊敬其他专业的学生，如何制定实验方案。本项目的目的是通过使用“螺旋”方法在微观实验中应用现代气相色谱/质谱（GC/MS）仪器来教授分子结构和分析方法的概念。在螺旋方法中，在一年或多年的几个实验室课程中，重新访问了GC/MS实验与分子结构之间的关系。通过将GC/MS的五个新实验引入入门水平有机和分析化学课程中，可以实现这一目标。新的有机实验是对经验和分子公式，宪法异构主义和立体异构主义概念的创新方法。分析实验是一种新方法的一部分，用于引入学生设计的方案，以分析生物学相关的化学样品。拟议的实验对于说明化学概念的意义很重要，这些化学概念是i）在现有实验室手册中忽略的，2）否则很难在微观中进行说明，或者3）与对传统化学实验室实验中经常忽略的生物学相关学科更感兴趣的学生有关。