Career: Design, Synthesis, and Investigation of the Self-Assembly and Self-Organization of Functional Multi-Stranded Helicoidal Architectures

通过这个职业奖项，有机和高分子化学项目支持普渡大学化学系的Hicham Fenniri博士的工作。这项研究的目的是：1)利用相邻互补单元之间的多个氢键，利用六聚体花环中的分子，合成具有预定结构的大型超分子组装；2)研究导致组装形成和稳定性的因素；3)利用组合化学和自组装相结合的方法开发人工传感器。在这个项目中合成的分子可能会在药物、生物传感器和分离中得到应用。这项建议的教育部分包括开发一门新的组合化学高级课程，并通过多种方式改进现有的一年级和二年级本科生的实验室课程，包括：1)改进实验讲义，2)报告实验结果的新模板，3)更好的助教培训，4)实验室中的在线化学搜索。使用PI进行研究的学生将在超分子材料的有机合成和组合化学领域学习有价值的技能。

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Hicham Fenniri of the Department of Chemistry at Purdue University. The research aims to: 1) synthesize large supramolecular assemblies with predefined architecture, using molecules held in hexameric rosettes by multiple hydrogen bonds between neighboring complementary units, 2) investigate the factors which lead to assembly formation and stability, and 3) develop artificial sensors using a combination of combinatorial chemistry and self-assembly. The molecules synthesized in this project might find uses in drugs, biosensors, and separations.The educational part of this proposal includes developing a new advanced course on combinatorial chemistry, and improving current laboratory courses for first and second year undergraduate students in a variety of ways, including: 1) improved laboratory hand-outs, 2) a new template to report experimental results, 3) better training of teaching assistants, and 4) on-line chemical searching in the laboratory. Students doing research with the PI will learn valuable skills in the areas of organic synthesis of supramolecular materials and combinatorial chemistry.