Career: Design, Synthesis, and Investigation of the Self-Assembly and Self-Organization of Functional Multi-Stranded Helicoidal Architectures

职业：功能多链螺旋结构的自组装和自组织的设计、合成和研究

• 批准号: 9875390
• 负责人: Hicham Fenniri
• 金额: $ 32.5万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9875390&HistoricalAwards=false
• 关键词: Career; Design; Synthesis; Investigation; Self

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Hicham Fenniri of the Department of Chemistry at Purdue University. The research aims to: 1) synthesize large supramolecular assemblies with predefined architecture, using molecules held in hexameric rosettes by multiple hydrogen bonds between neighboring complementary units, 2) investigate the factors which lead to assembly formation and stability, and 3) develop artificial sensors using a combination of combinatorial chemistry and self-assembly. The molecules synthesized in this project might find uses in drugs, biosensors, and separations.The educational part of this proposal includes developing a new advanced course on combinatorial chemistry, and improving current laboratory courses for first and second year undergraduate students in a variety of ways, including: 1) improved laboratory hand-outs, 2) a new template to report experimental results, 3) better training of teaching assistants, and 4) on-line chemical searching in the laboratory. Students doing research with the PI will learn valuable skills in the areas of organic synthesis of supramolecular materials and combinatorial chemistry.

有了这个职业奖，有机和高分子化学计划支持普渡大学化学系的Hicham Fenniri博士的工作。 该研究旨在：1）使用通过相邻互补单元之间的多个氢键保持在六聚体中的分子，合成具有预定结构的大型超分子组装体，2）研究导致组装体形成和稳定性的因素，以及3）使用组合化学和自组装的组合开发人工传感器。 在这个项目中合成的分子可能会在药物，生物传感器和分离中找到用途。这个提案的教育部分包括开发一个新的组合化学高级课程，并以各种方式改进当前本科一年级和二年级学生的实验室课程，包括：1）改进实验讲义，2）报告实验结果的新模板，3）更好地培训教学助理，以及4）实验室中的在线化学搜索。 与PI一起做研究的学生将学习超分子材料和组合化学的有机合成领域的宝贵技能。