CAREER: Statistics for Flow Cytometry and Freshman Seminars

9875598流式细胞术是一种分析和分选细胞的技术，需要对大量高维数据进行分析。在与流式细胞术的先驱小组之一的合作中，提案作者将开发必要的统计方法，将这项技术从手动操作的仪器转变为可访问互联网的数字图书馆。该研究将利用对数凹密度的一些惊人特性来解决混合分析和可视化中的各种统计和计算问题。研究人员还将组织夏季会议，让初级教员学习有效教授新生研讨会所需的工具，这种方法在许多大学中已经站稳脚跟。流式细胞术已成为一种广泛使用的细胞分析工具。直到20世纪80年代中期，这项技术几乎只在研究界使用。最近，它已成为临床环境中普遍使用的工具：它是HIV疾病分期的主要方法，通常用于检测白血病和淋巴瘤。现在几乎每家现代医院都有流式细胞仪。对结果数据的分析带来了相当大的统计挑战，迄今为止，这些挑战阻碍了对结果的有效数字化利用。研究者将用新的统计技术来解决这些问题。此外，拨款将支持由研究者组织的夏季会议，以传播有效教授新生研讨会所需的工具。这些研讨会旨在让本科生在早期阶段参与互动学习和研究，在许多大学越来越受欢迎。

9875598Flow cytometry is a technology for analyzing and sorting cells that requires the analysis of a large number of high-dimensional data. In collaboration with one of the pioneering flow cytometry groups the proposal writer will develop the statistical methods necessary to transform this technique from a manually operated apparatus to an internet-accessible digital library. The research will exploit some surprising properties of log-concave densities to solve various statistical and computational problems in mixture analysis and visualization. The investigator will also organize summer conferences for junior faculty members to learn the tools necessary to effectively teach freshman seminars, which are gaining a firm foothold in many universities.Flow cytometry has become a widely used tool to analyze cells. Until the mid 1980's, the technique was used almost exclusively in the research community. Recently, it has become a prevalent instrument in the clinical setting: it is the primary method for staging HIV disease, and it is commonly used to detect leukemia and lymphomas. Virtually every modern hospital now has flow cytometer. The analysis of the resulting data poses considerable statistical challenges, which so far have prevented an effective digital use of the results. The investigator will address these issues with novel statistical techniques. Further, the grant will support summer conferences organized by the investigator to disseminate the tools necessary to effectively teach freshman seminars. These seminars are designed to involve undergraduates in interactive learning and research at an early stage, and are getting increasingly popular at many universities.