U.S.-Australia Cooperative Research: Regulation of the Ryanodine-Receptor by the DHP-Receptor

美国-澳大利亚合作研究：DHP 受体对 Ryanodine 受体的调节

• 批准号: 9907646
• 负责人: Esther Gallant
• 金额: $ 5.85万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-15 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9907646&HistoricalAwards=false
• 关键词: U.S.; Australia; Cooperative; Research; Regulation

9907646GallantThis award supports collaboration between Dr. Esther Gallant, University of Minnesota, and Dr. Angela Dulhunty, Australian National University, on "Regulation of Ryanodine-Receptor by the DHP-Receptor". This is a project to study the regulation of the ryanodine receptor of muscle cells. Specific goals of the proposal are to use receptors reconstituted in artificial membranes to determine concentrations of co-proteins and ligands necessary for optimal channel function and to study channel function under these conditions when activated by peptides from the dihydropyridine receptor..

9907646加兰特该奖项支持明尼苏达大学的埃斯特·加兰特博士和澳大利亚国立大学的安吉拉·杜伦蒂博士在“通过DHP受体调节Ryanodine受体”方面的合作。这是一个研究肌肉细胞兰尼定受体调节的项目。该提案的具体目标是使用在人造膜上重组的受体来确定最佳通道功能所需的辅蛋白和配体的浓度，并研究在这些条件下被来自二氢吡啶受体的多肽激活时的通道功能。