Mechanism of glutamate transport from experimental and simulation studies

实验和模拟研究的谷氨酸转运机制

• 批准号: DP1092729
• 负责人: A/Prof Serdar Kuyucak
• 金额: $ 29.26万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-02-25 至 2013-12-10
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092729
• 关键词: Mechanism; glutamate; transport; experimental; simulation

Glutamate transporters play key roles in shaping the electrical signaling in the brain. Under conditions of stress or after a stroke, glutamate transporter function is impaired, which can lead to excessive levels of glutamate, cell death and impaired brain function. The project will help to decipher the operation of glutamate transporters at a molecular level and provide greater understanding of how glutamate levels are controlled, which is vital for developing better treatments for neurological disorders such as stroke. The project will also provide research training in experimental/computational molecular biology, which is a rapidly growing field underpinning the biotechnological and pharmaceutical industries.

谷氨酸转运蛋白在塑造大脑电信号传导方面发挥着关键作用。在压力条件下或中风后，谷氨酸转运蛋白功能受损，这可能导致谷氨酸水平过高、细胞死亡和大脑功能受损。该项目将有助于在分子水平上破译谷氨酸转运蛋白的运作，并更好地了解谷氨酸水平是如何控制的，这对于开发更好的治疗中风等神经系统疾病的方法至关重要。 该项目还将提供实验/计算分子生物学的研究培训，这是支撑生物技术和制药行业的一个快速发展的领域。