Quantum mechanical and dynamical investigation of ion channels

离子通道的量子力学和动力学研究

• 批准号: DP0878069
• 负责人: A/Prof Serdar Kuyucak
• 金额: $ 20.33万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-03-03 至 2012-03-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0878069
• 关键词: Quantum; mechanical; dynamical; investigation; ion

Many genetic diseases result from mutations in the genes that transcribe the channel proteins. Ion channels are also primary targets for development of therapeutic drugs for many ailments. Development of proper simulation tools is essential for a molecular-level understanding of their operation, which will be very helpful in finding treatments for genetic diseases as well as new drugs that target ion channels. Another aim of the project is to provide research training in computational biology. Research in this area is rapidly growing elsewhere but it has been rather neglected in Australia, and there is a shortage of researchers with such skills at present.

许多遗传性疾病是由转录通道蛋白的基因突变引起的。 离子通道也是许多疾病治疗药物开发的主要目标。开发适当的模拟工具对于在分子水平上理解它们的运作是必不可少的，这将非常有助于找到遗传疾病的治疗方法以及靶向离子通道的新药。 该项目的另一个目的是提供计算生物学方面的研究培训。 该领域的研究在其他地方正在迅速发展，但在澳大利亚却被忽视了，目前缺乏具有此类技能的研究人员。