A Gas Chromatograph-Mass Spectrometer for Curricular Improvement

用于课程改进的气相色谱-质谱仪

• 批准号: 9950226
• 负责人: David Richardson
• 金额: $ 4.63万
• 依托单位: Williams College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9950226&HistoricalAwards=false
• 关键词: Gas; Chromatograph; Mass; Spectrometer; Curricular

Gas Chromatography-Mass Spectrometry (GC-MS) is an indispensable analytical tool used widely in scientific research. Teaching this technique provides essential exposure to two central elements of chemical analysis: separation of mixtures and component identification through molecular weight determination and fragmentation analysis. This project uses a Hewlett-Packard 6890 bench top GC-MS system to enhance our curriculum at all levels, by implementing experiments demonstrating the power of GC-MS applications to general, organic, enzymological, environmental, and forensic chemistry. Experiments from the educational and research literature, as well as standard EPA methods, are being adapted to meet the needs of our undergraduates, including both science majors and nonmajors. Central to our curriculum revision are experiments that highlight now standard analytical techniques, such as positive ion chemical ionization analysis, negative ion chemical ionization analysis for trace level electrophilic analytes, and compound identification/structural hypothesis testing through spectrum library searches. Our major objective is to expand the quality of our existing laboratory program, and of our research experiences for undergraduate students, in order to enhance the overall level of preparation of our chemistry students, and to contribute towards faculty development in the areas of both teaching and research. We are sharing the curricular developments from this project with others through lab manual exchanges, faculty interactions, publications in refereed journals, scientific meeting presentations, and through our Department's WebPages. Our active membership in the New England Consortium for Undergraduate Science Education also provides an effective mechanism for dissemination of innovations to our sister institutions.

气相色谱-质谱联用技术（GC-MS）是科学研究中不可缺少的分析工具。教授这项技术提供了化学分析的两个核心要素：通过分子量测定和碎片分析分离混合物和成分鉴定。该项目使用惠普6890台式GC-MS系统，通过实施实验证明GC-MS应用于一般，有机，酶学，环境和法医化学的力量，以提高我们各级课程的质量。 从教育和研究文献的实验，以及标准的EPA方法，正在适应，以满足我们的本科生，包括科学专业和非专业的需求。 我们的课程修订的核心是强调现在标准分析技术的实验，如正离子化学电离分析，负离子化学电离分析痕量亲电分析物，并通过光谱库搜索化合物鉴定/结构假设检验。我们的主要目标是扩大我们现有的实验室计划的质量，以及我们为本科生提供的研究经验，以提高我们化学学生的整体准备水平，并为教学和研究领域的教师发展做出贡献。我们正在通过实验室手册交流，教师互动，在参考期刊，科学会议演示文稿中的出版物，并通过我们部门的网页与他人分享该项目的课程发展。我们在新英格兰本科科学教育联盟的积极成员也提供了一个有效的机制，传播创新，我们的姐妹机构。