The Design and Synthesis of Inhibitors of Human Immunodeficiency (HIV) Budding

我们有一种非常令人兴奋和革命性的药物设计方法，利用多肽的精致有力的作用，同时克服它们作为候选药物的缺点，因为它们在体内迅速降解。我们通过略微改变它们的化学结构，同时保持它们的生物活性来做到这一点。我们将把这种新的方法应用于一种新的蛋白质靶标，以抑制感染细胞中人类免疫缺陷(HIV)萌芽的主要步骤之一。这种新颖的化学和药物设计目标的独特结合使该项目具有很高的创新性，并具有加速确定艾滋病毒治疗新药的巨大潜力。

We have a very exciting and revolutionary approach to drug design by exploiting the exquisite potent action of peptides and at the same time overcome their shortcomings as drug candidates in that they are rapidly degraded in the body. We do this by slightly modifying their chemical structure but at the same time maintaining their biological activity. We will apply this new approach to a novel protein target to inhibit one of the main steps in the budding of Human Immunodeficiency (HIV) from infected cells. This unique combination of novel chemistry and drug design target makes this project highly innovative and with enormous potential to accelerate the identification of new drugs for HIV treatment.