The Design and Synthesis of Inhibitors of Human Immunodeficiency (HIV) Budding

人类免疫缺陷（HIV）出芽抑制剂的设计与合成

• 批准号: DP1093675
• 负责人: Prof Marie-Isabel Aguilar
• 金额: $ 18.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093675
• 关键词: Design; Synthesis; Inhibitors; Human; Immunodeficiency

We have a very exciting and revolutionary approach to drug design by exploiting the exquisite potent action of peptides and at the same time overcome their shortcomings as drug candidates in that they are rapidly degraded in the body. We do this by slightly modifying their chemical structure but at the same time maintaining their biological activity. We will apply this new approach to a novel protein target to inhibit one of the main steps in the budding of Human Immunodeficiency (HIV) from infected cells. This unique combination of novel chemistry and drug design target makes this project highly innovative and with enormous potential to accelerate the identification of new drugs for HIV treatment.

我们通过利用肽的精致有效作用，采用非常令人兴奋和革命性的药物设计方法，同时克服它们作为候选药物的缺点，即它们在体内快速降解。我们通过稍微修改它们的化学结构但同时保持其生物活性来做到这一点。我们将把这种新方法应用于新的蛋白质靶标，以抑制受感染细胞产生人类免疫缺陷（HIV）的主要步骤之一。这种新颖化学和药物设计目标的独特结合使该项目具有高度创新性，并具有加速艾滋病毒治疗新药鉴定的巨大潜力。