Helix VIII of G protein coupled receptors is a lipid-activated signalling sensor

G 蛋白偶联受体的 Helix VIII 是一种脂质激活信号传感器

• 批准号: nhmrc : 334049
• 负责人: Prof Marie-Isabel Aguilar
• 金额: $ 25.96万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/helix-viii-g-signalling-sensor/98992
• 关键词: Helix; VIII; protein; coupled; receptors

G protein-coupled receptors (GPCRs) are the largest superfamily of membrane-embedded receptors and represent prime targets for drug development. The molecular basis for their activation and regulation is poorly understood, particularly the contribution of the membrane environment to receptor function. Using a range of molecular and biophysical approaches and the angiotensin receptor as a model GPCR, studies are proposed to understand the role of the cell membrane in GPCR activation. The results will provide important new information on the molecular mechanism of GPCR regulation and exciting new approaches for drug design.

G蛋白偶联受体(GPCRs)是最大的膜包埋受体超家族，是药物开发的主要靶点。它们的激活和调控的分子基础还不是很清楚，特别是膜环境对受体功能的贡献。利用一系列的分子和生物物理方法，以血管紧张素受体为模型，提出了了解细胞膜在GPCR激活中的作用的研究。这些结果将为GPCR调控的分子机制提供重要的新信息，并为药物设计提供令人振奋的新方法。