PIPS regulate the type 1 angiotensin receptor
PIPS regulate the type 1 angiotensin receptor
批准号:
nhmrc : 1084462
负责人:
Prof Marie-Isabel Aguilar
金额:
$40.55万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
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英文摘要
The hormone angiotensin II (AngII) contributes broadly to the cardiovascular, endocrine, neural and metabolic systems. It binds to the angiotensin II type 1 (AT1) receptor and inappropriate activity leads to hypertension. Using a range of molecular and biophysical approaches and the angiotensin receptor as a model GPCR, we will study the role of the cell membrane in AT1 activation which may lead to new approaches for drug design.
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