The design and synthesis of angiotensin converting enzyme-2 (ACE2) inhibitors

血管紧张素转换酶2（ACE2）抑制剂的设计与合成

• 批准号: DP0557486
• 负责人: Prof Marie-Isabel Aguilar
• 金额: $ 28.43万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-03-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557486
• 关键词: design; synthesis; angiotensin; converting; enzyme

A vast number of current drugs on the market are inhibitors of enzymes whose action needs to be controlled in order to treat many conditions. This proposal will apply our new approaches to the design of enzyme inhibitors with superior therapeutic action. The benefits of this research reside in new treatments for a range of cardiovascular diseases (the 3rd largest cause of mortality in Australia) and provide a platform for new biotech companies to be formed in Australia.

目前市场上的大量药物都是酶的抑制剂，需要控制其作用才能治疗许多疾病。这项建议将把我们的新方法应用于设计具有优越治疗作用的酶抑制剂。这项研究的好处在于一系列心血管疾病(澳大利亚第三大死亡原因)的新疗法，并为澳大利亚新成立的生物技术公司提供了一个平台。