Acquisition of a High Performance Digital NMR Spectrometer Console for Studies in the Structure and Dynamics of Self-Assembled Systems.

CTS-9977269 John，Vijay T项目摘要获得高性能数字核磁共振光谱仪控制台，用于研究自组装系统的结构和动力学在过去的几十年里，核磁共振(核磁共振)谱已经发展成为一种探测化学结构和功能的精密技术。随着多核多维脉冲核磁共振和脉冲梯度自旋回波核磁共振的出现，现在已经出现了探索复杂体系的结构和动力学的技术，包括合成聚合物、表面活性剂聚集体等。该技术的应用跨越了物理、生命和工程科学领域。这一要求是为了增强杜兰大学的核磁共振能力，使我们能够使用这些先进的技术来解决具体的研究问题，并将我们的研究与教育相结合。杜兰大学将获得一个高性能的数字核磁共振光谱仪控制台。该控制台将与现有的高场磁铁(500 MHz)相耦合，构成该大学的先进核磁共振设施。仪器采购的一个主要目标是发展杜兰大学的核心能力，利用先进的核磁共振波谱解决特定生物大分子和两亲性系统中与自组装有关的问题。该提案是由五名研究人员撰写的，他们感兴趣的领域包括：(A)用于材料合成的表面活性剂微结构的自组装(B)双乳液中的运输和稳定性(C)遗传药物的膜渗透(D)蛋白质折叠和构象动力学(E)聚合物链动力学。研究人员将共同努力，发展先进核磁共振光谱学领域的跨学科核心能力。光谱仪将由杜兰的协调仪器设施(CIF)进行维护和操作。这是一个大学范围内的集中式设施，负责管理校园内的主要仪器设备。CIF的核心功能之一是为希望使用特定乐器的学生提供培训。主要研究人员致力于将他们的研究与教育相结合。在与CIF的合作下，新仪器将向该地区所有对使用核磁共振感兴趣的研究人员和学生开放。

CTS-9977269John, Vijay T Project SummaryAcquisition of a High Performance Digital NMR Spectrometer Console for Studies in the Structure and Dynamics of Self-Assembled SystemsOver the past couple of decades, nuclear magnetic resonance (NMR) spectroscopy has evolved to become an exquisite technique to probe chemical structure and function. With the advent of multinuclear and multidimensional pulse NMR, and pulsed gradient spinecho NMR, techniques now exist to probe the structure and dynamics of complex systems including synthetic polymers, surfactant aggregates, etc. Applications of the technique span the areas of the physical, life, and engineering sciences. This request is to enhance the NMR capabilities at Tulane to allow us to use these advanced techniques to solve specific research problems, and to integrate our research with education. Tulane University will acquire a high performance digital NMR spectrometer console. The console will be coupled to an existing high field magnet (500MHz) to constitute an advanced NMR facility at the university. A primary objective of instrument acquisition is the development of a core competence at Tulane, in the use of advanced NMR spectroscopy to solve problems related to self-assembly in specific biomacromolecular and amphiphilic systems. The proposal is written by five investigators with interests in (a) self-assembly of surfactant microstructures for materials synthesis (b) transport and stability in double emulsions (c) membrane penetration of genetic drugs (d) protein folding and conformational dynamics (e) polymer chain dynamics. The investigators will work together to develop an interdisciplinary core competence in advanced NMR spectroscopy. The spectrometer will be maintained and operated by a Coordinated Instrumentation Facility (CIF) at Tulane. This is a university-wide, centralized facility that operated the major instrumentation on campus. One of the core functions of the CIF is to provide training to students who wish to use specific instruments. The principal investigators are committed to integrate their research with education. In collaboration with the CIF, the new instrumentation will be made accessible to all researchers and students in the region interested in the use of NMR.