Acquisition of a High Performance Digital NMR Spectrometer Console for Studies in the Structure and Dynamics of Self-Assembled Systems.

购买高性能数字核磁共振波谱仪控制台，用于研究自组装系统的结构和动力学。

• 批准号: 9977269
• 负责人: Vijay John
• 金额: $ 22.91万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9977269&HistoricalAwards=false
• 关键词: Acquisition; Performance; Digital; NMR; Spectrometer

CTS-9977269John, Vijay T Project SummaryAcquisition of a High Performance Digital NMR Spectrometer Console for Studies in the Structure and Dynamics of Self-Assembled SystemsOver the past couple of decades, nuclear magnetic resonance (NMR) spectroscopy has evolved to become an exquisite technique to probe chemical structure and function. With the advent of multinuclear and multidimensional pulse NMR, and pulsed gradient spinecho NMR, techniques now exist to probe the structure and dynamics of complex systems including synthetic polymers, surfactant aggregates, etc. Applications of the technique span the areas of the physical, life, and engineering sciences. This request is to enhance the NMR capabilities at Tulane to allow us to use these advanced techniques to solve specific research problems, and to integrate our research with education. Tulane University will acquire a high performance digital NMR spectrometer console. The console will be coupled to an existing high field magnet (500MHz) to constitute an advanced NMR facility at the university. A primary objective of instrument acquisition is the development of a core competence at Tulane, in the use of advanced NMR spectroscopy to solve problems related to self-assembly in specific biomacromolecular and amphiphilic systems. The proposal is written by five investigators with interests in (a) self-assembly of surfactant microstructures for materials synthesis (b) transport and stability in double emulsions (c) membrane penetration of genetic drugs (d) protein folding and conformational dynamics (e) polymer chain dynamics. The investigators will work together to develop an interdisciplinary core competence in advanced NMR spectroscopy. The spectrometer will be maintained and operated by a Coordinated Instrumentation Facility (CIF) at Tulane. This is a university-wide, centralized facility that operated the major instrumentation on campus. One of the core functions of the CIF is to provide training to students who wish to use specific instruments. The principal investigators are committed to integrate their research with education. In collaboration with the CIF, the new instrumentation will be made accessible to all researchers and students in the region interested in the use of NMR.

CTS-9977269 John，Vijay T项目摘要为研究自组装系统的结构和动力学而购置高性能数字NMR光谱仪控制台在过去的几十年里，核磁共振（NMR）光谱学已经发展成为探测化学结构和功能的一种精密技术。 随着多核和多维脉冲核磁共振以及脉冲梯度自旋回波核磁共振的出现，现在已有技术来探测复杂系统的结构和动力学，包括合成聚合物、表面活性剂聚集体等。该技术的应用涵盖物理、生命等领域。和工程科学。 这一要求是为了提高杜兰大学的NMR能力，使我们能够使用这些先进的技术来解决具体的研究问题，并将我们的研究与教育相结合。 杜兰大学将获得一个高性能的数字核磁共振光谱仪控制台。 该控制台将与现有的高场磁体（500 MHz）耦合，构成该大学的先进NMR设施。 仪器采购的一个主要目标是在杜兰的核心竞争力的发展，在使用先进的NMR光谱来解决与特定的生物大分子和两亲性系统中的自组装相关的问题。 该提案是由五名研究人员撰写的，他们感兴趣的领域包括：（a）用于材料合成的表面活性剂微结构的自组装（B）双重乳液中的运输和稳定性（c）遗传药物的膜渗透（d）蛋白质折叠和构象动力学（e）聚合物链动力学。 研究人员将共同努力，发展先进的NMR光谱学的跨学科核心能力。光谱仪将由杜兰的协调仪器设施（CIF）维护和操作。 这是一个大学范围内的集中式设施，在校园内运行主要仪器。 CIF的核心职能之一是为希望使用特定仪器的学生提供培训。 主要研究人员致力于将他们的研究与教育相结合。 在与CIF的合作下，将向该地区对使用核磁共振感兴趣的所有研究人员和学生提供新的仪器。