Hydrogen Bonding, Ionic Solvation, and Anomeric Effects

氢键、离子溶剂化和端基异构效应

• 批准号: 9982103
• 负责人: Charles Perrin
• 金额: $ 45.3万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-15 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9982103&HistoricalAwards=false
• 关键词: Hydrogen; Bonding; Ionic; Solvation; Anomeric

This project employs nuclear magnetic resonance as a means of studying the nature of the hydrogen bond as well as other ion solvation and anomeric effects. A major objective of the proposed research is to determine experimentally the symmetry of a variety of hydrogen bonds. Concerning ion solvation, a newly developed NMR titration method is a powerful one for obtaining a quantitative measure of the steric demands of ionic species. Finally, clarification is sought as to the extent of anomeric stabilization when the electronegative groups are ionic.With this Award, the Organic and Macromolecular Chemistry Program continues its support of the research of Professor Charles L. Perrin of the University of California San Diego. Professor Perrin employs spectroscopic techniques similar to magnetic resonance imaging but on a molecular scale, in such a way that dynamic chemical processes and structures can be elucidated. The major aim of the research project is the characterization of the hydrogen bond, which is the type of bond by which the molecules of life adopt and maintain their three-dimensional shapes.

本计画以核磁共振作为研究氢键性质、其他离子溶剂化及异头效应的手段。 拟议的研究的一个主要目标是实验确定各种氢键的对称性。 关于离子溶剂化，一个新开发的NMR滴定方法是一个强大的获得离子物种的空间需求的定量测量。 最后，澄清的程度，端基稳定时，电负性基团是离子。有了这个奖项，有机和大分子化学计划继续支持查尔斯教授的研究。加州圣地亚哥大学的佩林说。 Perrin教授采用类似于磁共振成像的光谱技术，但在分子尺度上，以这种方式可以阐明动态化学过程和结构。 该研究项目的主要目的是表征氢键，这是生命分子采用和保持其三维形状的键类型。