SBIR Phase II: Optical Diffusion Tomography in Frequency Domain by the Elliptic Systems Method

SBIR 第二阶段：采用椭圆系统方法进行频域光学扩散断层扫描

• 批准号: 9983523
• 负责人: Jonathon Benson
• 金额: $ 40万
• 依托单位: Medical Optical Imaging Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9983523&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Optical; Diffusion

This Small Business Innovation Research Phase II project builds upon the concepts developed in the Phase I grant to develop a clinical prototype of an optical mammography device that could be used for breast cancer screening or diagnosis. The major technical obstacles to the development of an optical mammography device have been the need for imaging algorithms that are fast and accurate in the presence of scattered light, and fordeveloping measurement techniques that can collect enough photons in a safe and timely way to develop an accurate image. Phase I demonstrated the technical feasibility of a new approach to the algorithms and hardware. The software objectives of this project involve testing an approach to compute inclusion absorption coefficients, modifying the software to directly locate inclusions without transformation and developing a 3-D and GUI interface. Hardware objectives include developing a clinical prototype that would be safe and appropriate for imaging human subjects and calibrating and testing the hardware/software device on experimental data.

这个小型企业创新研究第二阶段项目建立在第一阶段赠款中开发的概念基础上，以开发一种可用于乳腺癌筛查或诊断的光学乳房X光照相设备的临床原型。开发光学乳房X光照相设备的主要技术障碍是需要在存在散射光的情况下快速而准确的成像算法，以及开发能够以安全和及时的方式收集足够的光子以产生准确图像的测量技术。第一阶段论证了一种新的算法和硬件方法的技术可行性。该项目的软件目标包括测试一种计算夹杂物吸收系数的方法，修改软件以直接定位夹杂物而不进行变换，并开发一个三维和图形用户界面。硬件目标包括开发一种安全和适合于为人体受试者成像的临床原型，以及根据实验数据校准和测试硬件/软件设备。