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COLLABORATIVE RESEARCH: Ecological and Evolutionary Physiology of the Stress Response and Stress Proteins

COLLABORATIVE RESEARCH: Ecological and Evolutionary Physiology of the Stress Response and Stress Proteins
合作研究:应激反应和应激蛋白的生态学和进化生理学
批准号:
9986158
负责人:
Martin Feder
金额:
$29.35万
依托单位:
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-05-01 至 2004-04-30

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英文摘要
A major issue in ecological and evolutionary physiology is the relationship among the traits of complex organisms, organisms' ability to exploit diverse environments, and species' persistence in time. The proposed investigation in part uses the heat-shock protein Hsp70 in Drosophila as a model trait/organism/system to address this issue. In response to heat or other stresses, nearly all organisms express heat-shock proteins (I-Isps), highly-conserved proteins that contribute to stress tolerance by functioning as molecular chaperones. Research supported by previous NSF awards has established that experimental manipulation of copy number of the hsp7O gene of Drosophila, which encodes Hsp7O, is sufficient to cause changes in outright survival of natural thermal stress, and that natural populations vary in Hsp70 expression in ways that are consistent with it being adaptive. The proposed research will build upon a recent and significant preliminary finding: that not only does Hsp70 protect against heat death, it also mitigates major morphological anomalies in wings and abdomens of adults that have undergone exposure to natural thermal stress during their pre-adult stages. Such morphological abnormalities can occur in 10% of surviving adults and potentially compromise courtship and mating, territorial defense, oviposition, flight, and water balance, each a likely component of fitness. The proposed research will first relate the incidence of these abnormalities to the temperatures that non-adult Drosophila undergo in the laboratory, and then verify that similar relationships occur for Drosophila in nature. Next, the proposed research will establish the effect of these abnormalities on courtship and mating, territorial defense, oviposition, flight, and water balance. Finally, the proposed experiment will genetically and experimentally manipulate Hsp expression to establish the role of Hsp7O in protecting or mitigating morphological defects. The projected outcome of the proposed research has immense potential to integrate molecular, genetic, functional, and evolutionary perspectives to advance understanding of adaptation.
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Ecological and Evolutionary Physiology of the Stress Response and Stress Proteins
  • 批准号:
    0641278
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $55.99万
  • 财政年份:
    2007
  • 负责人:
    Martin Feder
  • 依托单位:
FIBR: Planning: Proteomic Analysis of Critical Targets of Environmental Stress
  • 批准号:
    0307044
  • 项目类别:
    Standard Grant
  • 资助金额:
    $4.99万
  • 财政年份:
    2003
  • 负责人:
    Martin Feder
  • 依托单位:
Ecological and Evolutionary Physiology of the Stress Response and Stress Proteins
  • 批准号:
    0316627
  • 项目类别:
    Standard Grant
  • 资助金额:
    $58.12万
  • 财政年份:
    2003
  • 负责人:
    Martin Feder
  • 依托单位:
DISSERTATION RESEARCH: Evolutionary Physiology of Heat-Shock Gene Expression
  • 批准号:
    0206582
  • 项目类别:
    Standard Grant
  • 资助金额:
    $0.99万
  • 财政年份:
    2002
  • 负责人:
    Martin Feder
  • 依托单位:
国内基金
海外基金
Research on Quantum Field Theory without a Lagrangian Description
  • 批准号:
    24ZR1403900
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    SATOSHI NAWATA
  • 依托单位:
Cell Research
Cell Research
Cell Research (细胞研究)