NANOSCALE: An Electronic Component from Protein Self-Assembly

纳米尺度：蛋白质自组装的电子元件

• 批准号: 9986431
• 负责人: Patrick Van Roey
• 金额: $ 10万
• 依托单位: Health Research Incorporated/New York State Department of Health
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9986431&HistoricalAwards=false
• 关键词: NANOSCALE; Electronic; Component; Protein; Self

The goal of this proposal is to produce a self-assembling diode from protein.Demonstration of such a device would be an important first step to the development of a new class of biologically-based electronic components, ultimately designed to self-assemble into complex nanometer-scale devices.Intermediate tasks toward the development of the first such device are proposed as follows. 1) Optimization of the surface residues of the metaloprotein pseudoazurin to improve crystallization properties. 2) Modification of the protein to covalently cross-link within the crystal to provide mechanical stability and to improve intermolecular conduction. 3) Characterization of electric conduction properties of the crystal. 4) Modification of those properties through addition of an additional metal center, chemical modification of the protein, or some combination of these two methods. 5) Growth of modified pseudoazurin protein crystals with optimized redox and conduction properties,followed by growth of an additional layer of protein differing in those properties. 6) Characterization of the directional conduction through the resulting device.

该提案的目标是用蛋白质生产自组装二极管。这种设备的演示将是开发新型生物基电子元件的重要第一步，最终设计用于自组装成复杂的纳米级设备。开发第一个此类设备的中间任务建议如下。 1) 金属蛋白伪天青表面残基的优化，以提高结晶性能。 2) 修饰蛋白质以在晶体内共价交联，以提供机械稳定性并改善分子间传导。 3）晶体导电性能的表征。 4) 通过添加额外的金属中心、蛋白质的化学修饰或这两种方法的某种组合来改变这些特性。 5) 生长具有优化的氧化还原和传导特性的改性假天青蛋白晶体，随后生长具有不同特性的附加层蛋白。 6) 通过所得器件的定向传导的表征。