NANOSCALE: Engineered Alpha Helices for Pore Transport Regulation

NANOSCALE：用于孔传输调节的工程阿尔法螺旋

• 批准号: 9986538
• 负责人: Peter Kilpatrick
• 金额: $ 10万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9986538&HistoricalAwards=false
• 关键词: NANOSCALE; Engineered; Alpha; Helices; Pore

AbstractProposal number: BES-9986538Proposal type: Response to NSF 99-109, Exploratory Research on Biosystems at the NanoscalePrincipal investigator: Peter K. KilpatrickAffiliation: North Carolina State UniversityNANOSCALE: Engineered Alpha Helices for Pore-Transport RegulationThis exploratory project investigates the fabrication and efficacy of nanostructured block-copolymer membranes containing helical polymers. The objective is to mimic biological systems in order to achieve high transport selectivity for biological solutes.Various polymeric microstuctures that form helices with varying degrees of hydrophobicity will be synthesized and assembled in planar phospholipid monolayers and in vesicular membranes. The ability of the various structures will be probed to determine their ability to control solute transport through the membranes according the hydrophobicity of the helix periphery and the resulting pore sizes. Transport measurements are being done with radioactive and fluorescent solutes.

摘要提案编号：BES-9986538提案类型：对NSF 99-109《纳米尺度生物系统探索性研究》的回复。KilpatrickAffiliation： 北卡罗来纳州州立大学纳米尺度：工程α螺旋孔运输调节这个探索性的项目研究的制造和含有螺旋聚合物的纳米结构嵌段共聚物膜的功效。 目的是模拟生物系统，以实现高的运输选择性的生物solutes.Various聚合物的微结构，形成不同程度的疏水性的螺旋将被合成和组装在平面磷脂单层和囊泡膜。 将探测各种结构的能力，以根据螺旋外围的疏水性和所得孔径确定其控制溶质通过膜转运的能力。 运输测量正在进行放射性和荧光溶质。