NANOSCALE: Engineered Alpha Helices for Pore Transport Regulation

建议编号：BES-9986538建议类型：响应NSF 99-109，生物系统在纳米尺度上的探索性研究首席研究员：Peter K.Kilpatrick从属：北卡罗来纳州立大学NANOSCALE：用于孔道传输调节的工程阿尔法螺旋这个探索性项目调查含有螺旋聚合物的纳米结构嵌段共聚物膜的制备和效果。其目的是模拟生物体系，以实现生物溶液的高选择性传输。各种形成不同程度疏水性螺旋的聚合物微结构将被合成并组装在平面磷脂单分子膜和囊膜中。将根据螺旋外围的疏水性和由此产生的孔径大小来探讨各种结构的能力，以确定它们控制溶质通过膜的运输的能力。正在使用放射性和荧光溶质进行传输测量。

AbstractProposal number: BES-9986538Proposal type: Response to NSF 99-109, Exploratory Research on Biosystems at the NanoscalePrincipal investigator: Peter K. KilpatrickAffiliation: North Carolina State UniversityNANOSCALE: Engineered Alpha Helices for Pore-Transport RegulationThis exploratory project investigates the fabrication and efficacy of nanostructured block-copolymer membranes containing helical polymers. The objective is to mimic biological systems in order to achieve high transport selectivity for biological solutes.Various polymeric microstuctures that form helices with varying degrees of hydrophobicity will be synthesized and assembled in planar phospholipid monolayers and in vesicular membranes. The ability of the various structures will be probed to determine their ability to control solute transport through the membranes according the hydrophobicity of the helix periphery and the resulting pore sizes. Transport measurements are being done with radioactive and fluorescent solutes.