SGER: Maintenance of an Outbred High-Altitude Adapted Colony of Deer Mice

DBI-9987605 Hammond，Kimberly A.该项目旨在支持来自加州白色山脉高海拔种群的鹿鼠（Peromyscus maniculatus）群体。 这个物种是独一无二的，因为它携带的血红蛋白多态性可能赋予生活在高海拔缺氧和寒冷条件下的优势。 因此，该物种是一个理想的模式，开始大规模的研究，以适应高海拔或其他缺氧条件下的温血动物。 该菌落也不含汉他病毒（Sin Nombre株），因此它是汉他病毒研究的宝贵资源，并且没有健康或安全风险。 最后，将殖民地远系繁殖，并保持最大的杂合性。殖民地将代表一个优良的、无汉他病毒的原种，它将可用于其他研究人员在小型哺乳动物中研究汉他病毒及其相关生理学。 此外，殖民地将是研究小型哺乳动物海拔驯化和适应的生态学和进化生物学的极好资源。 这笔资金将用于支持建立一个繁殖群，当它们可以被维护并广泛提供给其他研究人员时，该繁殖群将被存放在南卡罗来纳州大学的Peromyscus股票中心。

DBI-9987605Hammond, Kimberly A.This project is to support a colony of deer mice (Peromyscus maniculatus) that are derived from a high altitude population in the White Mountains of California. This species is unique because it carries a hemoglobin polymorphism that may confer an advantage for living at high altitudes under reduced oxygen and cold conditions. Thus, the species is an ideal model for the initiation of a large-scale study of adaptation to high altitude or other hypoxic conditions in warm-blooded animals. This colony is also Hanta virus (Sin Nombre strain) free so it is a valuable resource for Hanta virus research and represents no health or safety risks. Finally, the colony is outbred and has been maintained to preserve maximum heterozygosity.The colony will represent an excellent, Hanta virus free stock that will be of use to other researchers for the study of Hanta virus and its associated physiology in small mammals. In addition, the colony will be an excellent resource for the study of the ecology an evolutionary biology of altitudinal acclimation and adaptation in small mammals. The funds will support building of a breeding colony that will be deposited in the Peromyscus Stock Center at the University of South Carolina when they can be maintained and made widely available to other researchers.