SGER: Maintenance of an Outbred High-Altitude Adapted Colony of Deer Mice

SGER：近交系高海拔适应鹿鼠群体的维护

• 批准号: 9987605
• 负责人: Kimberly Hammond
• 金额: $ 2.88万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-15 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9987605&HistoricalAwards=false
• 关键词: SGER; Maintenance; Outbred; Altitude; Adapted

DBI-9987605Hammond, Kimberly A.This project is to support a colony of deer mice (Peromyscus maniculatus) that are derived from a high altitude population in the White Mountains of California. This species is unique because it carries a hemoglobin polymorphism that may confer an advantage for living at high altitudes under reduced oxygen and cold conditions. Thus, the species is an ideal model for the initiation of a large-scale study of adaptation to high altitude or other hypoxic conditions in warm-blooded animals. This colony is also Hanta virus (Sin Nombre strain) free so it is a valuable resource for Hanta virus research and represents no health or safety risks. Finally, the colony is outbred and has been maintained to preserve maximum heterozygosity.The colony will represent an excellent, Hanta virus free stock that will be of use to other researchers for the study of Hanta virus and its associated physiology in small mammals. In addition, the colony will be an excellent resource for the study of the ecology an evolutionary biology of altitudinal acclimation and adaptation in small mammals. The funds will support building of a breeding colony that will be deposited in the Peromyscus Stock Center at the University of South Carolina when they can be maintained and made widely available to other researchers.

DBI-9987605 Hammond，Kimberly A.这个项目是为了支持一个鹿鼠群体(Permyscus Manulatus)，这些鹿鼠来自加利福尼亚州怀特山的一个高海拔种群。这个物种是独一无二的，因为它携带着一种血红蛋白多态，这种多态可能会赋予在低氧和寒冷条件下生活在高海拔地区的优势。因此，该物种是启动温血动物对高海拔或其他低氧条件适应的大规模研究的理想模型。该菌落也不含汉塔病毒，因此它是汉塔病毒研究的宝贵资源，不存在健康或安全风险。最后，该群体被杂交并被维持以保持最大的杂合性。该群体将代表一个优秀的、无汉塔病毒的种群，将被其他研究人员用于研究小型哺乳动物中的汉塔病毒及其相关生理学。此外，该群体将成为研究小型哺乳动物海拔适应和适应的生态学和进化生物学的极好资源。这笔资金将支持建立一个繁殖群体，当它们可以维护并广泛提供给其他研究人员时，将存放在南卡罗来纳大学的Permyscus股票中心。