Multiple Metal-Carbon Bonds, Metallacycles, and Catalytic Reactions Involving Olefins and Acetylenes

理查德·施罗克博士，麻省理工学院化学系，由化学部无机、生物无机和有机金属计划支持，研究金属-碳多键和金属环。其目的是开发涉及烯烃和乙炔的新催化反应。该项目将专注于合成含有联苯酚和联萘酚配体的新型钼催化剂。这些物种催化的不对称烯烃歧化反应的机理将被确定。将研究相关的钨配合物，并探索它们催化的不对称烯烃歧化反应。催化剂在特定反应产物的合成中很重要，它们的使用可以显著节省能源和化学物质。这项工作的目标是系统地设计附着在活性金属中心上的基团，以便控制它们的催化效果。所研究的特定体系包含氮基(氨基)配体和早期过渡金属。人们将设计出通向新的不对称分子的简便路线。这将通过提供获得纯对映异构体的新方法而对例如制药业产生重大影响。

Dr. Richard Schrock, Department of Chemistry, Massachusetts Institute of Technology, is supported by the Inorganic, Bioinorganic, and Organometallic Program of the Chemistry Division for research into metal-carbon multiple bonds and metallacycles. The objective is to develop new catalytic reactions involving olefins and acetylenes. The project will concentrate on the synthesis of new molybdenum catalysts that contain biphenolate and binaphtholate ligands. The mechanism of asymmetric olefin metathesis catalyzed by these species will be determined. Related tungsten complexes will be studied and asymmetric olefin metathesis catalyzed by them will be probed. Catalysts are important in the synthesis of specific reaction products and their use can result in significant energy and chemical savings. The goal of this work is to systematically design groups attached to active metal centers in order to control their catalytic effects. The specific systems studied contain nitrogen-based (amido) ligands and early transition metals. Facile routes to new asymmetric molecules will be devised. This will have great impact on, e.g., the pharmaceutical industry by providing new ways of obtaining pure enatio-isomers.