Multiple Metal-Carbon Bonds, Metallacycles, and Catalytic Reactions Involving Olefins and Acetylenes

Richard Schrock博士，麻省理工学院化学系，由化学部无机、生物无机和有机金属项目支持，研究金属-碳多键和金属循环。目的是开发涉及烯烃和乙炔的新的催化反应。该项目将集中于合成含有双酚酯和双萘酚酯配体的新型钼催化剂。研究了这些物质催化不对称烯烃复分解的机理。研究相关的钨配合物，探讨其催化的不对称烯烃复分解反应。催化剂在特定反应产物的合成中是很重要的，使用它们可以节省大量的能源和化学物质。本工作的目标是系统地设计附着于活性金属中心的基团，以控制其催化效果。所研究的特定体系含有氮基（氨基）配体和早期过渡金属。新的不对称分子的便捷路线将被设计出来。这将对制药工业产生重大影响，因为它提供了获得纯异位异构体的新方法。

Dr. Richard Schrock, Department of Chemistry, Massachusetts Institute of Technology, is supported by the Inorganic, Bioinorganic, and Organometallic Program of the Chemistry Division for research into metal-carbon multiple bonds and metallacycles. The objective is to develop new catalytic reactions involving olefins and acetylenes. The project will concentrate on the synthesis of new molybdenum catalysts that contain biphenolate and binaphtholate ligands. The mechanism of asymmetric olefin metathesis catalyzed by these species will be determined. Related tungsten complexes will be studied and asymmetric olefin metathesis catalyzed by them will be probed. Catalysts are important in the synthesis of specific reaction products and their use can result in significant energy and chemical savings. The goal of this work is to systematically design groups attached to active metal centers in order to control their catalytic effects. The specific systems studied contain nitrogen-based (amido) ligands and early transition metals. Facile routes to new asymmetric molecules will be devised. This will have great impact on, e.g., the pharmaceutical industry by providing new ways of obtaining pure enatio-isomers.