Multiple Metal-Carbon Bonds, Metallacycles, and Catalytic Reactions Involving Olefins and Acetylenes

马萨诸塞州理工学院化学系的Richard Schrock博士得到化学系无机、生物无机和有机物项目的支持，研究金属-碳多重键和金属杂环。目的是开发涉及烯烃和乙炔的新的催化反应。该项目将集中于合成含有联苯酚盐和联萘酚盐配体的新型钼催化剂。这些物种催化不对称烯烃复分解反应的机理将被确定。对相关的钨配合物进行了研究，并探讨了它们催化的烯烃不对称复分解反应。催化剂在特定反应产物的合成中很重要，它们的使用可以显著节省能源和化学品。 这项工作的目标是系统地设计连接到活性金属中心的基团，以控制其催化作用。 研究的特定系统包含氮基（酰胺基）配体和早期过渡金属。将设计出制备新的不对称分子的简便途径。这将产生巨大的影响，例如，通过提供获得纯的对映异构体的新方法，

Dr. Richard Schrock, Department of Chemistry, Massachusetts Institute of Technology, is supported by the Inorganic, Bioinorganic, and Organometallic Program of the Chemistry Division for research into metal-carbon multiple bonds and metallacycles. The objective is to develop new catalytic reactions involving olefins and acetylenes. The project will concentrate on the synthesis of new molybdenum catalysts that contain biphenolate and binaphtholate ligands. The mechanism of asymmetric olefin metathesis catalyzed by these species will be determined. Related tungsten complexes will be studied and asymmetric olefin metathesis catalyzed by them will be probed. Catalysts are important in the synthesis of specific reaction products and their use can result in significant energy and chemical savings. The goal of this work is to systematically design groups attached to active metal centers in order to control their catalytic effects. The specific systems studied contain nitrogen-based (amido) ligands and early transition metals. Facile routes to new asymmetric molecules will be devised. This will have great impact on, e.g., the pharmaceutical industry by providing new ways of obtaining pure enatio-isomers.