Multiple Metal - Carbon Bonds, Metallacycles, and Catalytic Reactions Involving Olefins and Acetylenes

该奖项支持麻省理工学院Richard R. Shrock教授关于不对称烯烃复分解的合成和机理方面的研究，以及涉及三胺胺和二胺胺配体的早期过渡金属的有机金属化学。烯烃分馏是指两种烯烃以2+2加成，以经济有效的方式生成两种新的烯烃。所研究的催化剂是唯一已知的用于不对称复分解反应的有效催化剂，对制备手性药物具有重要意义。早期过渡金属配合物与新的三胺胺和二胺胺配体将进行研究，以描绘这些配合物如何促进化学计量和催化反应。将研究有机金属配合物，以提高其催化有机转化的能力，特别是那些需要合成手性药物的能力。

This award supports research by Professor Richard R. Shrock of the Massachusetts Institute of Technology concerning the synthetic and mechanistic aspects of asymmetric olefin metathesis and the organometallic chemistry of the early transition metals involving triamidoamine and diamidoamine ligands. Olefin metathesis involves the 2+2 addition of two olefins to yield two new olefins in an economically efficient manner. The catalysts under study are the only known efficient catalysts for asymmetric metathesis reactions and are of interest for preparing chiral pharmaceuticals. Early transition metal complexes with new triamidoamine and diamidoamine ligands will be investigated in order to delineate how such complexes can facilitate both stoichiometric and catalytic reactions.Organometallic complexes will be investigated in order to improve their ability to catalyze organic transformations, particularly those needed for the synthesis of chiral drugs.