Multiple Metal - Carbon Bonds, Metallacycles, and Catalytic Reactions Involving Olefins and Acetylenes

多金属-碳键、金属环以及涉及烯烃和乙炔的催化反应

• 批准号: 0138495
• 负责人: Richard Schrock
• 金额: --
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0138495&HistoricalAwards=false
• 关键词: Multiple; Metal; Carbon; Bonds; Metallacycles

This award supports research by Professor Richard R. Shrock of the Massachusetts Institute of Technology concerning the synthetic and mechanistic aspects of asymmetric olefin metathesis and the organometallic chemistry of the early transition metals involving triamidoamine and diamidoamine ligands. Olefin metathesis involves the 2+2 addition of two olefins to yield two new olefins in an economically efficient manner. The catalysts under study are the only known efficient catalysts for asymmetric metathesis reactions and are of interest for preparing chiral pharmaceuticals. Early transition metal complexes with new triamidoamine and diamidoamine ligands will be investigated in order to delineate how such complexes can facilitate both stoichiometric and catalytic reactions.Organometallic complexes will be investigated in order to improve their ability to catalyze organic transformations, particularly those needed for the synthesis of chiral drugs.

该奖项支持麻省理工学院的 Richard R. Shrock 教授关于不对称烯烃复分解的合成和机械方面以及涉及三酰氨基胺和二酰氨基胺配体的早期过渡金属的有机金属化学的研究。 烯烃复分解涉及两种烯烃的2+2加成，以经济有效的方式产生两种新的烯烃。 正在研究的催化剂是唯一已知的用于不对称复分解反应的有效催化剂，并且对于制备手性药物具有重要意义。 将研究具有新的三酰氨基胺和二酰氨基胺配体的早期过渡金属络合物，以描述此类络合物如何促进化学计量和催化反应。将研究有机金属络合物，以提高其催化有机转化的能力，特别是合成手性药物所需的有机转化的能力。