Multiple Metal - Carbon Bonds, Metallacycles, and Catalytic Reactions Involving Olefins and Acetylenes

该奖项支持Richard R. Shrock，马萨诸塞州理工学院，关于不对称烯烃复分解的合成和机理方面以及涉及三酰氨基胺和二酰氨基胺配体的早期过渡金属的有机金属化学。 烯烃复分解涉及两种烯烃的2+2加成以经济有效的方式产生两种新烯烃。 所研究的催化剂是唯一已知的用于不对称复分解反应的有效催化剂，并且对制备手性药物感兴趣。 早期的过渡金属配合物与新的triamidoamine和diamidoamine配体将被研究，以描绘如何这类配合物可以促进化学计量和催化反应。有机配合物将被研究，以提高其催化有机转化的能力，特别是那些需要的手性药物的合成。

This award supports research by Professor Richard R. Shrock of the Massachusetts Institute of Technology concerning the synthetic and mechanistic aspects of asymmetric olefin metathesis and the organometallic chemistry of the early transition metals involving triamidoamine and diamidoamine ligands. Olefin metathesis involves the 2+2 addition of two olefins to yield two new olefins in an economically efficient manner. The catalysts under study are the only known efficient catalysts for asymmetric metathesis reactions and are of interest for preparing chiral pharmaceuticals. Early transition metal complexes with new triamidoamine and diamidoamine ligands will be investigated in order to delineate how such complexes can facilitate both stoichiometric and catalytic reactions.Organometallic complexes will be investigated in order to improve their ability to catalyze organic transformations, particularly those needed for the synthesis of chiral drugs.