Multiple Metal-Carbon Bonds, Metallacycles, and Catalytic Olefin Metathesis Reactions

多重金属-碳键、金属环和催化烯烃复分解反应

• 批准号: 1111133
• 负责人: Richard Schrock
• 金额: $ 57万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1111133&HistoricalAwards=false
• 关键词: Multiple; Metal; Carbon; Bonds; Metallacycles

This award in the Chemical Synthesis (SYN) program supports work by Professor Richard R. Schrock at the Massachusetts Institute of Technology to carry out fundamental studies on olefin metathesis catalysts based on molybdenum or tungsten. Olefin metathesis is a catalytic reaction that consists of breaking and rearranging carbon-carbon double bonds in organic molecules. The benefit of the reaction to mankind was recognized through the 2005 Nobel Prize in Chemistry to Schrock, Grubbs, and Chauvin. New developments in the last two years have led to new types of molybdenum and tungsten catalysts that are much more reactive and selective than any previous catalysts. The proposed work includes an investigation of the interconversion and relative reactivity of syn and anti alkylidene isomers and devising routes to new MonoAlkoxide Pyrrolide (MAP) catalysts and related species, including selective catalysts supported on silica or alumina.The olefin metathesis reaction has revolutionized the synthesis of organic molecules relevant to natural and unnatural products for treatment of diseases such as cancers and AIDS, as well as the synthesis of specialty polymers. Newly developed applications include the synthesis of organic molecules from renewable resources such as seed oils and the selective synthesis of organic molecules that contain only a cis carbon-carbon double bond, the type that is most common in natural products and the most useful in organic synthesis.

该化学合成 (SYN) 项目奖项支持麻省理工学院 Richard R. Schrock 教授开展基于钼或钨的烯烃复分解催化剂的基础研究。 烯烃复分解是一种催化反应，包括有机分子中碳-碳双键的断裂和重新排列。 施罗克、格拉布斯和肖文荣获 2005 年诺贝尔化学奖，表彰了该反应对人类的益处。 过去两年的新发展催生了新型钼和钨催化剂，它们比以前的任何催化剂都更具反应性和选择性。 拟议的工作包括研究顺式和反亚烷基异构体的相互转化和相对反应性，并设计新的单醇盐吡咯化物（MAP）催化剂和相关物质的路线，包括负载在二氧化硅或氧化铝上的选择性催化剂。烯烃复分解反应彻底改变了与天然和非天然产物相关的有机分子的合成，用于治疗疾病，例如 癌症和艾滋病，以及特种聚合物的合成。 新开发的应用包括从种子油等可再生资源合成有机分子，以及选择性合成仅含有顺式碳碳双键的有机分子，这种类型在天然产物中最常见，在有机合成中最有用。