Hyperthermophilic Enzyme Modification of Polysaccharide Biopolymers: Interrelationship Between Biocatalysis and Rheology
多糖生物聚合物的高温酶改性:生物催化与流变学之间的相互关系
基本信息
- 批准号:0002260
- 负责人:
- 金额:$ 36.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-08-15 至 2006-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This proposal builds on an ongoing interdisciplinary effort to examine the interrelationship between enzymatic modification of water-soluble polymers and the resulting rheological consequences. The expanded scope of this project has the following objectives: (1) biochemical and biophysical characterization of promising wild-type and mutated hyperthermophilic galactomannanases and galactosidases, with respect to polysaccharide modification; (2) investigation of the mobility and distribution of enzymes within the biopolymer matrix during enzymatic modification along with the concomitant changes in the aggregation pattern of the biopolymer-enzyme system; and (3) correlation of enzyme activity to changes in rheology and galactomannan molecular architecture. Such an effort, based on the collective expertise of this research team, i.e., polysaccharide systems, enzymology at elevated temperatures, and the rheology of gels and solutions, will provide a comprehensive understanding of the fundamental and technological issues governing polymer modification resulting from enzyme action. While the focus here is on galactomannans, the long-term impact of this work will extend to strategic biocatalytic approaches to enhance the efficacy and use of other carbohydrate biopolymers.
这一建议建立在一项正在进行的跨学科努力的基础上,以检查水溶性聚合物的酶促修饰与由此产生的流变学后果之间的相互关系。该项目的扩大范围有以下目标:(1)在多糖修饰方面,对有希望的野生型和突变型超高温半乳甘露聚糖酶和半乳糖苷酶进行生化和生物物理表征;(2)研究酶在酶修饰过程中酶在生物聚合物基质中的流动性和分布以及伴随着生物聚合物-酶系统聚集模式的变化;以及(3)酶活性与流变学和半乳甘露聚糖分子结构变化的关系。这项工作基于该研究团队的集体专业知识,即多糖系统、高温下的酶学以及凝胶和溶液的流变学,将使人们全面了解酶作用导致的聚合物改性的基本和技术问题。虽然这里的重点是半乳甘露聚糖,但这项工作的长期影响将延伸到战略性生物催化方法,以提高其他碳水化合物生物聚合物的有效性和用途。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Saad Khan其他文献
Security auditing in the fog
雾中的安全审计
- DOI:
10.1145/3018896.3056808 - 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
S. Parkinson;Yongrui Qin;Saad Khan;M. Vallati - 通讯作者:
M. Vallati
Exploring perceptions of decision-makers and specialists in defensive machine learning cybersecurity applications: The need for a standardised approach
探索决策者和专家对防御性机器学习网络安全应用的看法:需要标准化方法
- DOI:
10.1016/j.cose.2023.103694 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Omar Alshaikh;Siôn Parkinson;Saad Khan - 通讯作者:
Saad Khan
Caffeine intoxication treated with hemodialysis
血液透析治疗咖啡因中毒
- DOI:
10.1111/sdi.13169 - 发表时间:
2023 - 期刊:
- 影响因子:1.6
- 作者:
Saad Khan;Kavita Babu;Rohan Sidhu;M. Niemi - 通讯作者:
M. Niemi
Hyperspectral Remote Sensing for Detection of Natural Hydrocarbon Seeps
- DOI:
- 发表时间:
2016-01 - 期刊:
- 影响因子:0
- 作者:
Saad Khan - 通讯作者:
Saad Khan
Using computational systematic social observation to identify environmental correlates of fear of crime
- DOI:
10.1186/s40163-024-00242-6 - 发表时间:
2024-12-19 - 期刊:
- 影响因子:2.600
- 作者:
Réka Solymosi;Simon Parkinson;Andrea Pődör;Saad Khan;Muhammad Khan - 通讯作者:
Muhammad Khan
Saad Khan的其他文献
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{{ truncateString('Saad Khan', 18)}}的其他基金
Acquisition of an Extrusion System for Innovative Polymer Processing and New Materials Research Programs
采购用于创新聚合物加工和新材料研究项目的挤出系统
- 批准号:
0115741 - 财政年份:2001
- 资助金额:
$ 36.73万 - 项目类别:
Standard Grant
Acquisition of GPC/Static Light Scattering System for Polymer, Membrane and Colloid Science Research Program
购置 GPC/静态光散射系统用于聚合物、膜和胶体科学研究计划
- 批准号:
9703973 - 财政年份:1997
- 资助金额:
$ 36.73万 - 项目类别:
Standard Grant
Thermophilic Enzyme Hydrolysis of Water-Soluble Polymers: Interrelationship Between Biocatalysis and Rheology
水溶性聚合物的嗜热酶水解:生物催化与流变学之间的相互关系
- 批准号:
9707160 - 财政年份:1997
- 资助金额:
$ 36.73万 - 项目类别:
Continuing Grant
相似国自然基金
木质纤维素高效水解多酶混合物(multi-enzyme cocktails)的高通量分析及其理性定制
- 批准号:21176106
- 批准年份:2011
- 资助金额:60.0 万元
- 项目类别:面上项目
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