Enzyme-mediated modification of peptide hydrogels to tailor them for drug delivery and tissue engineering

酶介导的肽水凝胶修饰，使其适合药物输送和组织工程

• 批准号: 2276784
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2276784
• 关键词: Enzyme; mediated; modification; peptide; hydrogels

This biotechnology project which is conducted in collaboration with the custom peptide synthesis company Pepceuticals, will involve the synthesis of small peptides, known to self-assemble into hydrogels capable of either encapsulating drugs or supporting mammalian cell growth and modifying a proportion of these peptides to provide additional anchor points, chemical queues and other functionality that will significantly enhance the capabilities of the hydrogel. These modifications will be conducted using either enzyme-mediated processes or a variety of bioconjugation methods. The scaffolds produced will find future uses in regenerative medicine and wound healing.

该生物技术项目与定制肽合成公司Pepceuticals合作进行，将涉及小肽的合成，已知小肽能够自组装成能够封装药物或支持哺乳动物细胞生长的水凝胶，并修饰这些肽的一部分以提供额外的锚点，化学队列和其他功能，这将显着增强水凝胶的能力。这些修饰将使用酶介导的方法或各种生物缀合方法进行。所生产的支架将在再生医学和伤口愈合中找到未来的用途。