Support a Workshop on Marine Microbial Genomics

支持海洋微生物基因组学研讨会

• 批准号: 0002871
• 负责人: Stephen Cary
• 金额: $ 1.99万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-15 至 2001-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0002871&HistoricalAwards=false
• 关键词: Support; Workshop; Marine; Microbial; Genomics

It is clear that the technological power of high throughput sequencing has revolutionized our capabilities to examine the biochemical intricacies of organisms at the genomic level. This is best represented by the remarkable achievement of fully sequencing the human genome two years earlier than projected. Projects are now underway to fully sequence the mouse, maize, rice and numerous other biomedically important microbial genomes. In addition, during the last five years we have seen over 25 microbial genomes fully sequences with over 95 currently underway. Most of these organisms are of biomedical importance.Over the past 15 years we have begun to understand more about the diversity, distribution, and evolution of free-living bacteria. Environmental microbiology, like its sister fields, has greatly benefited from the rapid development in molecular biological technology. Numerous microbial phylogenetic studies from a range of environments have revealed that less that 1% of the bacteria have been successfully cultivated. While we now know something about what individuals make up these unique microbial communities, we have very little information about what they are doing or are capable of doing. The recent development of high throughput genomic sequencing technology and microarray expression screening provides us with the opportunity to discover the metabolic capacity of bacteria that have eluded cultivation and to better understand how bacteria interact under the constraints of their environment. The field of marine environmental genomics is in its infancy but has the potential to unleash an unprecedented wave of information critical to understanding microbial systems in the marine environment. Advancements in this area are currently suppressed due to the lack of accessibility to the current technology. The technology required is extremely costly and is certainly out of the range of the individual investigator. Here the scientists will convene a task group of investigators from the marine microbial arena to discuss the direction the community should take in microbial genomics. Inclusion of industrial components to this workshop is essential in hopes that a partnership could be forged that would provide continued access to the developing technology.

很明显，高通量测序的技术力量已经彻底改变了我们在基因组水平上检查生物体生物化学复杂性的能力。 人类基因组完全测序的显著成就比预期提前了两年，就是最好的代表。 目前正在进行的项目是对小鼠、玉米、水稻和许多其他生物医学上重要的微生物基因组进行完全测序。 此外，在过去的五年中，我们已经看到超过25个微生物基因组的完整序列，目前正在进行的超过95个。 在过去的15年里，我们开始更多地了解自由生活的细菌的多样性、分布和进化。 环境微生物学和它的姐妹学科一样，从分子生物学技术的迅速发展中受益匪浅。 来自一系列环境的许多微生物系统发育研究表明，只有不到1%的细菌被成功培养。 虽然我们现在知道了一些关于个体组成这些独特的微生物群落的信息，但我们对它们正在做什么或能够做什么的信息很少。 高通量基因组测序技术和微阵列表达筛选的最新发展为我们提供了发现逃避培养的细菌的代谢能力和更好地理解细菌在其环境的约束下如何相互作用的机会。 海洋环境基因组学领域尚处于起步阶段，但有可能释放出对了解海洋环境中的微生物系统至关重要的前所未有的信息浪潮。 由于缺乏现有技术，这一领域的进展目前受到抑制。 所需的技术极其昂贵，肯定超出了调查员个人的能力范围。 在这里，科学家们将召集一个由海洋微生物竞技场的调查人员组成的工作组，讨论该社区在微生物基因组学方面应该采取的方向。 将工业组成部分纳入该讲习班至关重要，希望能够建立一种伙伴关系，继续提供不断发展的技术。