Support a Workshop on Marine Microbial Genomics

支持海洋微生物基因组学研讨会

• 批准号: 0002871
• 负责人: Stephen Cary
• 金额: $ 1.99万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-15 至 2001-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0002871&HistoricalAwards=false
• 关键词: Support; Workshop; Marine; Microbial; Genomics

It is clear that the technological power of high throughput sequencing has revolutionized our capabilities to examine the biochemical intricacies of organisms at the genomic level. This is best represented by the remarkable achievement of fully sequencing the human genome two years earlier than projected. Projects are now underway to fully sequence the mouse, maize, rice and numerous other biomedically important microbial genomes. In addition, during the last five years we have seen over 25 microbial genomes fully sequences with over 95 currently underway. Most of these organisms are of biomedical importance.Over the past 15 years we have begun to understand more about the diversity, distribution, and evolution of free-living bacteria. Environmental microbiology, like its sister fields, has greatly benefited from the rapid development in molecular biological technology. Numerous microbial phylogenetic studies from a range of environments have revealed that less that 1% of the bacteria have been successfully cultivated. While we now know something about what individuals make up these unique microbial communities, we have very little information about what they are doing or are capable of doing. The recent development of high throughput genomic sequencing technology and microarray expression screening provides us with the opportunity to discover the metabolic capacity of bacteria that have eluded cultivation and to better understand how bacteria interact under the constraints of their environment. The field of marine environmental genomics is in its infancy but has the potential to unleash an unprecedented wave of information critical to understanding microbial systems in the marine environment. Advancements in this area are currently suppressed due to the lack of accessibility to the current technology. The technology required is extremely costly and is certainly out of the range of the individual investigator. Here the scientists will convene a task group of investigators from the marine microbial arena to discuss the direction the community should take in microbial genomics. Inclusion of industrial components to this workshop is essential in hopes that a partnership could be forged that would provide continued access to the developing technology.

显然，高通量测序的技术能力彻底改变了我们在基因组水平上检查生物体生化复杂性的能力。 这是两年前比预期的早期对人类基因组进行完全测序的显着成就的最佳代表。 现在正在进行项目，以完全序列小鼠，玉米，大米和许多其他重要重要的微生物基因组。 此外，在过去的五年中，我们看到超过25个微生物基因组完全序列，目前正在进行95多个微生物基因组。 这些生物大多数都具有生物医学的重要性。在过去的15年中，我们已经开始更多地了解自由生活细菌的多样性，分布和演变。 与其姊妹领域一样，环境微生物学已从分子生物技术的快速发展中受益匪浅。 来自各种环境的许多微生物系统发育研究表明，成功培养的1％的细菌的1％。 虽然我们现在知道个人构成这些独特的微生物社区的知识，但我们对他们正在做什么或能够做的事情的信息很少。 高通量基因组测序技术和微阵列表达筛查的最新发展使我们有机会发现养育培养的细菌的代谢能力，并更好地了解细菌在其环境的约束下如何相互作用。 海洋环境基因组学领域仍处于起步阶段，但有可能释放出对理解海洋环境中微生物系统的前所未有的信息浪潮。 由于目前的技术缺乏可访问性，目前在该领域的进步被抑制。 所需的技术非常昂贵，并且肯定超出了个人调查员的范围。 在这里，科学家将召集来自海洋微生物领域的研究人员的任务组，以讨论社区对微生物基因组学应采取的方向。 将工业组成部分纳入本研讨会至关重要，希望可以建立合作伙伴关系，以继续访问发展技术。