Support a Workshop on Marine Microbial Genomics

支持海洋微生物基因组学研讨会

• 批准号: 0002871
• 负责人: Stephen Cary
• 金额: $ 1.99万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-15 至 2001-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0002871&HistoricalAwards=false
• 关键词: Support; Workshop; Marine; Microbial; Genomics

It is clear that the technological power of high throughput sequencing has revolutionized our capabilities to examine the biochemical intricacies of organisms at the genomic level. This is best represented by the remarkable achievement of fully sequencing the human genome two years earlier than projected. Projects are now underway to fully sequence the mouse, maize, rice and numerous other biomedically important microbial genomes. In addition, during the last five years we have seen over 25 microbial genomes fully sequences with over 95 currently underway. Most of these organisms are of biomedical importance.Over the past 15 years we have begun to understand more about the diversity, distribution, and evolution of free-living bacteria. Environmental microbiology, like its sister fields, has greatly benefited from the rapid development in molecular biological technology. Numerous microbial phylogenetic studies from a range of environments have revealed that less that 1% of the bacteria have been successfully cultivated. While we now know something about what individuals make up these unique microbial communities, we have very little information about what they are doing or are capable of doing. The recent development of high throughput genomic sequencing technology and microarray expression screening provides us with the opportunity to discover the metabolic capacity of bacteria that have eluded cultivation and to better understand how bacteria interact under the constraints of their environment. The field of marine environmental genomics is in its infancy but has the potential to unleash an unprecedented wave of information critical to understanding microbial systems in the marine environment. Advancements in this area are currently suppressed due to the lack of accessibility to the current technology. The technology required is extremely costly and is certainly out of the range of the individual investigator. Here the scientists will convene a task group of investigators from the marine microbial arena to discuss the direction the community should take in microbial genomics. Inclusion of industrial components to this workshop is essential in hopes that a partnership could be forged that would provide continued access to the developing technology.

显然，高通量测序的技术力量彻底改变了我们在基因组水平上检查生物体生化复杂性的能力。 最能体现这一点的是比预计提前两年对人类基因组进行全面测序所取得的非凡成就。 目前正在进行对小鼠、玉米、水稻和许多其他生物医学上重要的微生物基因组进行全面测序的项目。 此外，在过去五年中，我们已经对超过 25 个微生物基因组进行了完整测序，其中超过 95 个目前正在进行中。 这些生物体大多数都具有生物医学重要性。在过去的 15 年里，我们已经开始更多地了解自由生活细菌的多样性、分布和进化。 环境微生物学与其姊妹领域一样，极大地受益于分子生物技术的快速发展。 来自各种环境的大量微生物系统发育研究表明，只有不到 1% 的细菌被成功培养。 虽然我们现在对这些独特的微生物群落的个体组成有所了解，但我们对他们正在做什么或有能力做什么的信息却知之甚少。 近年来高通量基因组测序技术和微阵列表达筛选的发展为我们提供了发现未培养细菌的代谢能力的机会，并更好地了解细菌在环境限制下如何相互作用。 海洋环境基因组学领域尚处于起步阶段，但有潜力释放出前所未有的信息浪潮，这对于了解海洋环境中的微生物系统至关重要。 由于缺乏现有技术，该领域的进步目前受到抑制。 所需的技术极其昂贵，而且肯定超出了个体研究者的能力范围。 在这里，科学家们将召集一个由海洋微生物领域的研究人员组成的任务组，讨论社区在微生物基因组学方面应采取的方向。 将工业组件纳入本次研讨会至关重要，希望能够建立合作伙伴关系，持续提供开发技术。