The biological and pathological functions of TDP-43

TDP-43的生物学和病理功能

• 批准号: DP1096674
• 负责人: Prof Lars Ittner
• 金额: $ 33.44万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-02-11 至 2013-02-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096674
• 关键词: biological; pathological; functions; TDP; 43

The social and economic burden of neurodegenerative such as MND is enormous. A key histopathological hallmark of this and many other related diseases are deposits of the protein TDP-43. Our research aims at understanding its largely unknown functions, for example by generating transgenic animal models. These will form the base for the development for a TDP-43-directed drug treatment. The national benefit of this research is manifold: by deciphering basic biological mechanisms, patenting new data, developing treatment strategies for un-curable and fatal disorders, and expanding links to Australian biotech and international pharmaceutical companies.

神经退行性疾病如MND的社会和经济负担是巨大的。这种疾病和许多其他相关疾病的一个关键的组织病理学标志是蛋白质TDP-43的沉积。我们的研究旨在了解其大部分未知的功能，例如通过产生转基因动物模型。这些将构成开发tdp -43导向药物治疗的基础。这项研究对国家的好处是多方面的：破译基本的生物机制，为新数据申请专利，为无法治愈和致命的疾病制定治疗策略，扩大与澳大利亚生物技术和国际制药公司的联系。