Novel pathomechanisms and therapeutic approaches in Alzheimer's disease and related dementias

阿尔茨海默病和相关痴呆的新病理机制和治疗方法

• 批准号: nhmrc : 1003083
• 负责人: Prof Lars Ittner
• 金额: $ 53.62万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-pathomechanisms-therapeutic-related-dementias/108892
• 关键词: Novel; pathomechanisms; therapeutic; approaches; Alzheimer

Currently, over 200,000 Australians are affected by Alzheimer's disease (AD) or frontotemporal lobar degeneration (FTLD), causing a huge socio-economic damage. To overcome the lack of effective treatments, we need to understand the underlying causes and translate them into therapy. Using state-of-the-art cell culture and genetic mouse models, I will reveal fundamental processes in AD and related dementias, and develop tailored treatments to battle these devastating disorders.

目前，超过20万澳大利亚人患有阿尔茨海默病（AD）或额颞叶变性（FTLD），造成了巨大的社会经济损失。为了克服缺乏有效治疗的问题，我们需要了解根本原因并将其转化为治疗方法。使用最先进的细胞培养和遗传小鼠模型，我将揭示AD和相关痴呆症的基本过程，并开发量身定制的治疗方法来对抗这些毁灭性的疾病。