Systemic regulation of neuronal circuits in cognition and behaviour

认知和行为中神经元回路的系统调节

• 批准号: DP170100843
• 负责人: Prof Lars Ittner
• 金额: $ 24.35万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100843
• 关键词: Systemic; regulation; neuronal; circuits; cognition

This project aims to understand systemic regulation of behaviour and cognition in the central nervous system (CNS). The adrenal gland (AG) is an endocrine organ that regulates behaviour and cognition, but the molecular mechanisms underlying the regulatory axis between the CNS and AG are poorly understood. The AG selectively and highly expresses p38, a member of the MAP kinase family, while mice that lack p38 suffer memory and behavioural deficits. This project will study p38’s role in systemic CNS function. It aims to understand brain function and systemic regulation of cognition and behaviour, thereby contributing to a deeper understanding of brain function and paving the way for new preventive treatments and medical care strategies.

该项目旨在了解中枢神经系统（CNS）行为和认知的系统调节。肾上腺（AG）是调节行为和认知的内分泌器官，但人们对中枢神经系统和肾上腺之间调节轴的分子机制知之甚少。 AG 选择性地高度表达 p38（MAP 激酶家族的成员），而缺乏 p38 的小鼠会出现记忆和行为缺陷。该项目将研究 p38 在系统中枢神经系统功能中的作用。它旨在了解大脑功能以及认知和行为的系统调节，从而有助于更深入地了解大脑功能，并为新的预防性治疗和医疗保健策略铺平道路。