Systemic regulation of neuronal circuits in cognition and behaviour

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This project aims to understand systemic regulation of behaviour and cognition in the central nervous system (CNS). The adrenal gland (AG) is an endocrine organ that regulates behaviour and cognition, but the molecular mechanisms underlying the regulatory axis between the CNS and AG are poorly understood. The AG selectively and highly expresses p38, a member of the MAP kinase family, while mice that lack p38 suffer memory and behavioural deficits. This project will study p38’s role in systemic CNS function. It aims to understand brain function and systemic regulation of cognition and behaviour, thereby contributing to a deeper understanding of brain function and paving the way for new preventive treatments and medical care strategies.