SBIR Phase I: Latent-Reactive Surface Modification Reagents for Biofilm Control

SBIR 第一阶段：用于生物膜控制的潜在反应性表面改性试剂

• 批准号: 0060593
• 负责人: Patrick Guire
• 金额: $ 9.95万
• 依托单位: SurModics, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0060593&HistoricalAwards=false
• 关键词: SBIR; Phase; Latent; Reactive; Surface

This Small Business Innovation Research (SBIR) Phase I project aims to develop new reagents subject to thermal activation for bonding water-soluble microbicidal polymers and surfactants to the lumen surface of a variety of opaque tubing materials at temperatures compatible with the plastics. Materials have been developed with bulk physical properties needed for transport of water and aqueous mixtures; however, the development of biofilm on the wet surfaces is a continuing serious problem in the dental, pharmaceutical, food processing, and marine transport industries. Surface modification of water lines could decrease the formation of biofilm while retaining the desired bulk properties of the tubing. Photochemistry has been proven commercially successful in enhancing the surface properties of medical devices with radical-based surface modification initiated by RF plasma or ultraviolet light. However, these energy sources are not effective for modification the inner surfaces of 'opaque' tubes such as water lines used with dental units and plastic plumbing in pharmaceutical plants. This project is designed to develop latent-reactive radical generators activatible with external source energy that penetrates these 'opaque' devices. This innovative approach to scheduled activation of radical generators is expected to facilitate the coupling to many 'inert' surfaces that cannot be activated with external light or plasma sources.Microbial colonization and biofilm formation remain a major cost and threat to human health and product quality for dental and pharmaceutical industries, health care and public lodging, and marine vessel utilization. Successful development of microbicidal and antifouling coating technology for the luminal surface of opaque transport and storage vessels for aqueous liquid ingestible products, constitute a significant market.

该小型企业创新研究(SBIR)第一阶段项目旨在开发可热激活的新试剂，用于在与塑料兼容的温度下将水溶性杀菌聚合物和表面活性剂粘合到各种不透明管材的管腔表面。已开发的材料具有运输水和含水混合物所需的散装物理性能；然而，在牙科、制药、食品加工和海洋运输行业，湿表面生物膜的发展仍然是一个严重的问题。对输水管进行表面改性可以减少生物膜的形成，同时保持管材所需的整体性能。光化学已被证明在商业上成功地通过射频等离子体或紫外光引发的基于自由基的表面改性来增强医疗器械的表面性能。然而，这些能源不能有效地改善“不透明”管道的内表面，例如用于牙科设备的水管和制药厂的塑料管道。该项目旨在开发潜在的反应性自由基生成器，该生成器可通过穿透这些不透明设备的外部能源激活。这种按计划激活自由基生成器的创新方法有望促进与许多无法用外部光或等离子体源激活的“惰性”表面的耦合。微生物定植和生物膜形成仍然是牙科和制药行业、医疗保健和公共住宿以及海洋船只使用的人类健康和产品质量的主要成本和威胁。成功开发了用于不透明运输和储存容器的管腔表面杀菌和防污涂层技术，用于含水液体可食用产品，构成了一个重要的市场。