Mechanismen der Evolution des Hepatitis C Virus - Bedeutung der Sequenzvariabilität für die antivirale Immunantwort (B01)

丙型肝炎病毒的进化机制 - 序列变异对于抗病毒免疫反应的重要性 (B01)

• 批准号: 141722714
• 金额: --
• 依托单位: Arbeitsgruppe Bioinformatics and Computational Biophysics
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/141722714?language=en
• 关键词: Mechanismen; der; Evolution; des; Hepatitis

Analysis of Hepatitis C Virus (HCV) evolution can aid vaccine development by identification of regions under selection pressure by the immune system. In this project the influence of host genotypes on viral evolution will be analyzed for different genes that shape the immune response, and the impact of differential population allele frequencies in China versus Germany will be addressed. The earliest events of HCV transmission and evolution will be dissected by characterization of viral evolution during liver transplantation. Taken together, these studies will help to elucidate the determinants of HCV evolution and the impact of HCV sequence diversity on the immune Response.

丙型肝炎病毒（HCV）进化的分析可以通过识别免疫系统选择压力下的区域来帮助疫苗开发。在本项目中，将针对塑造免疫应答的不同基因分析宿主基因型对病毒进化的影响，并将讨论中国与德国人群等位基因频率差异的影响。HCV传播和演变的最早期事件将通过肝移植过程中病毒演变的特征来剖析。总之，这些研究将有助于阐明HCV进化的决定因素和HCV序列多样性对免疫应答的影响。