Mechanismen der Evolution des Hepatitis C Virus - Bedeutung der Sequenzvariabilität für die antivirale Immunantwort (B01)

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Analysis of Hepatitis C Virus (HCV) evolution can aid vaccine development by identification of regions under selection pressure by the immune system. In this project the influence of host genotypes on viral evolution will be analyzed for different genes that shape the immune response, and the impact of differential population allele frequencies in China versus Germany will be addressed. The earliest events of HCV transmission and evolution will be dissected by characterization of viral evolution during liver transplantation. Taken together, these studies will help to elucidate the determinants of HCV evolution and the impact of HCV sequence diversity on the immune Response.