POWRE: Pulmonary Nitric Oxide and Adaptation to High-Altitude Hypoxia

一氧化氮是一种由身体产生的气体，用于执行许多功能，包括确保氧气从肺部扩散到血液。 该项目将开发和验证一种测量肺中产生的一氧化氮量的技术，已知肺是合成的主要场所。 一氧化氮产生的变化被认为对人们居住在氧气有限的极端环境中的能力有影响，例如在高海拔地区。了解安第斯、西藏和埃塞俄比亚高原的数百万高海拔原住民如何适应以确保在严重低氧条件下的氧气输送，将增进对人类适应极端环境和环境变化过程的了解。 这个POWRE项目将为Beall提供她无法获得的培训和技术发展机会。 这一开发和测试阶段将在受控的实验室环境中进行，以便在偏远的高海拔地点进行实地研究之前建立技术。

Nitric oxide is a gas produced by the body to perform many functions, including ensuring the diffusion of oxygen from the lungs to the blood. This project will develop and validate a technique to measure the amount of nitric oxide produced in the lungs, known to be a major site of synthesis. Variation in the production of nitric oxide is thought to have consequences for people's ability to inhabit extreme environments where oxygen is limiting, such as those at high altitudes. Understanding how the millions of high-altitude natives of the Andean, Tibetan and Ethiopian Plateaus have adapted to ensure oxygen delivery under conditions of severe low oxygen will improve knowledge of the processes of human adaptation to extreme environments and to environmental change. This POWRE project will provide Beall the opportunity for training and technique development that she cannot obtain otherwise. This developmental and testing phase will be undertaken in a controlled, laboratory environment in order to establish the technique before undertaking field research in remote, high-altitude sites.