POWRE: Pulmonary Nitric Oxide and Adaptation to High-Altitude Hypoxia

POWRE：肺一氧化氮与高原缺氧适应

• 批准号: 0074567
• 负责人: Cynthia Beall
• 金额: $ 7.5万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0074567&HistoricalAwards=false
• 关键词: POWRE; Pulmonary; Nitric; Oxide; Adaptation

Nitric oxide is a gas produced by the body to perform many functions, including ensuring the diffusion of oxygen from the lungs to the blood. This project will develop and validate a technique to measure the amount of nitric oxide produced in the lungs, known to be a major site of synthesis. Variation in the production of nitric oxide is thought to have consequences for people's ability to inhabit extreme environments where oxygen is limiting, such as those at high altitudes. Understanding how the millions of high-altitude natives of the Andean, Tibetan and Ethiopian Plateaus have adapted to ensure oxygen delivery under conditions of severe low oxygen will improve knowledge of the processes of human adaptation to extreme environments and to environmental change. This POWRE project will provide Beall the opportunity for training and technique development that she cannot obtain otherwise. This developmental and testing phase will be undertaken in a controlled, laboratory environment in order to establish the technique before undertaking field research in remote, high-altitude sites.

一氧化氮是人体产生的一种气体，具有多种功能，包括确保氧气从肺部扩散到血液中。 该项目将开发并验证一种技术来测量肺部产生的一氧化氮的量，已知肺部是一氧化氮的主要合成场所。 人们认为，一氧化氮产生的变化会对人们在氧气有限的极端环境（例如高海拔地区）的生存能力产生影响。了解安第斯高原、青藏高原和埃塞俄比亚高原的数百万高海拔居民如何适应在严重低氧条件下确保氧气输送，将提高对人类适应极端环境和环境变化过程的了解。 这个 POWRE 项目将为 Beall 提供她无法通过其他方式获得的培训和技术开发机会。 这一开发和测试阶段将在受控的实验室环境中进行，以便在偏远高海拔地区进行实地研究之前建立该技术。