Hypoxemia in the Tibetan Autonomous Region of China

这项拨款允许比尔博士进行人类生物学研究 中华人民共和国西藏自治区帕拉的 大约170名男女游牧民（15岁至18岁）， .85），以研究居住在海拔4900之间。 海拔5450米，该项目的目标是 了解人们如何适应全年居住在这样的 高地比尔医生会测量血红蛋白的分布 浓度、动脉血氧饱和度百分比和 通风.研究参与者将提供手指采血 血液学分析的样本，并接受非侵入性 血氧测定法还将测量静息通气量。这 将产生关于年龄和性别差异的基本流行病学数据， 这些参数，并允许比尔博士测试的假设， 血红蛋白浓度与 和动脉血氧饱和度百分比。比尔博士也 假设，有一个积极的关联之间的 动脉血氧饱和度和通气量的百分比。 这是一个非常有趣的研究群体，因为它 常年生活在如此高的海拔也是 有趣的是，西藏人似乎适应了氧气， 与南美人不同的高海拔压力 他们生活在安第斯山脉。这后一组展品桶胸部 以及更高的血红蛋白浓度这些特征 在西藏人中似乎是不存在的。 这项研究很重要，因为它将增加我们的 了解人类如何适应生理压力。这可能有帮助 在高原反应的管理，并将有助于打开这个 对美国研究者来说是世界上非常有趣的地方。我

This grant permits Dr. Beall to conduct human biological research in Phala, Tibet Autonomous Region, Peoples Republic of China. The approximately 170 male and female nomads (between the ages of 15 .85) to be studied reside at high altitudes of between 4900 . 5450 m above sea level and the goal of this project is to understand how people adapt to year round habitation at such heights. Dr. Beall will measure the distribution of hemoglobin concentration, percent arterial oxygen saturation and ventilation. Study participants will provide fingerstick blood samples for hematological analysis and undergo noninvasive oximetry. Resting ventilation volumes will also be measured. This will yield basic epidemiologic data on age and sex differences in these parameters and allow Dr. beall to test the hypothesis that an inverse association exists between hemoglobin concentration and percent arterial oxygen saturation. Dr. Beall also hypothesiszes that there is a positive association between the percent of arterial oxygen saturation and ventilation. This is an extremely interesting study population because it resides year round at such a high altitude. It is also interesting because it appears that Tibetians adapt to the oxygen stress imposed by high altitude differently from South Americans who live in the Andes. This latter group exhibit barrel chests and higher levels of hemoglobin concentration. These features appear to be abscent in Tibetans. This research is important because it will increase our understanding of how humans adapt to physical stress. It may aid in the management of altitude sickness and will help to open this extremely interesting part of the world to U.S. reseachers. I