Genetics of Oxygen Transport in High Altitude Natives

高海拔地区原住民氧气运输的遗传学

• 批准号: 9221724
• 负责人: Cynthia Beall
• 金额: $ 19.08万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-03-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9221724&HistoricalAwards=false
• 关键词: Genetics; Oxygen; Transport; Altitude; Natives

Human biologists have studied the adaptations of high altitude populations for decades, and have established the existence of physiological differences between high altitude Andean and Himalayan groups (and low altitude groups). However, no progress has been made in determining the mode of inheritance of critical components in the oxygen transport systems of either Himalayan or Andean high altitude populations, so that currently it is not possible to deduce that the differences are hereditary, environomental, or a product of gene-environment interactions. Employing a novel statistical genetic analytic technique on family data from these areas, this project will address this important issue. A pilot study suggests the chances for success are excellent.

人类生物学家研究了高海拔的适应性 几十年来，人们已经建立了 高海拔安第斯山脉和 喜马拉雅山脉群（和低海拔群）。 然而，没有进展 在确定关键的遗传方式方面已经取得了进展， 喜马拉雅山脉或喜马拉雅山脉的氧气运输系统中的成分， 安第斯山的高海拔人口，所以目前它不是 可以推断出这些差异是遗传的， 是基因与环境相互作用的产物。 采用一种新的统计遗传分析技术， 从这些地区的家庭数据，该项目将解决这一问题， 重要的问题。 一项试点研究表明， 都很棒