POWRE: Synthesis of Taxane Diterpenes via Pi-Allyl Palladium Complexes

POWRE：通过 Pi-烯丙基钯配合物合成紫杉烷二萜

• 批准号: 0074969
• 负责人: Nicole Bennett
• 金额: $ 7.49万
• 依托单位: Hope College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0074969&HistoricalAwards=false
• 关键词: POWRE; Synthesis; Taxane; Diterpenes; via

This POWRE award by the Chemistry Division will support Dr. Nicole Bennett in developing a research program in efficient organo-metallic synthesis at Hope College. The specific objective of this research will be to develop little used synthetic procedures to prepare taxane diterpenes, a class of compounds that have found use as anticancer agents. This project will allow Dr. Bennett to expand the repertory of undergraduate research projects at Hope, especially in the areas of synthetic organometallic chemistry, stereochemistry and structure interpretation by magnetic resonance. The project will also support Dr. Bennett's efforts to incorporate modern synthetic chemical techniques in the undergraduate chemistry curriculum at Hope College and will provide chemistry undergraduates at the college with experience in specialized synthetic chemical procedures, advanced chemical structural concepts, use of the chemical literature, presentation of research results, etc. that will better prepare them for graduate training in the field.

化学部颁发的POWRE奖将支持Nicole班尼特博士在霍普学院开发有效的有机金属合成研究项目。这项研究的具体目标是开发很少使用的合成方法来制备紫杉烷二萜，这是一类已发现可用作抗癌剂的化合物。该项目将使班尼特博士能够扩大霍普大学本科生研究项目的范围，特别是在合成有机金属化学、立体化学和磁共振结构解释等领域。该项目还将支持班尼特博士将现代合成化学技术纳入霍普学院本科化学课程的努力，并将为该学院的化学本科生提供专业合成化学程序、先进化学结构概念、化学文献的使用、研究成果的介绍等方面的经验，这将使他们为该领域的研究生培训做好更好的准备。