POWRE: Synthesis of Taxane Diterpenes via Pi-Allyl Palladium Complexes

化学部颁发的POWRE奖将支持Nicole Bennett博士在霍普学院开发高效有机金属合成研究项目。这项研究的具体目标是开发很少使用的合成程序来制备紫杉烷二萜，紫杉烷二萜是一类已被发现用作抗癌剂的化合物。该项目将使贝内特博士能够扩大霍普大学本科生研究项目的储备，特别是在合成有机金属化学、立体化学和磁共振结构解释领域。该项目还将支持贝内特博士将现代合成化学技术纳入霍普学院本科生化学课程的努力，并将为该学院的化学本科生提供专业合成化学程序、先进的化学结构概念、化学文献的使用、研究成果的展示等方面的经验，这将为他们在该领域的研究生培训做好更好的准备。

This POWRE award by the Chemistry Division will support Dr. Nicole Bennett in developing a research program in efficient organo-metallic synthesis at Hope College. The specific objective of this research will be to develop little used synthetic procedures to prepare taxane diterpenes, a class of compounds that have found use as anticancer agents. This project will allow Dr. Bennett to expand the repertory of undergraduate research projects at Hope, especially in the areas of synthetic organometallic chemistry, stereochemistry and structure interpretation by magnetic resonance. The project will also support Dr. Bennett's efforts to incorporate modern synthetic chemical techniques in the undergraduate chemistry curriculum at Hope College and will provide chemistry undergraduates at the college with experience in specialized synthetic chemical procedures, advanced chemical structural concepts, use of the chemical literature, presentation of research results, etc. that will better prepare them for graduate training in the field.