Asymmetric Cycloaddition Methodology for Natural Product Synthesis

该项目探索了各种结构类型的天然产物全合成的新战略和新方法。该项目的重点是环加成化学，重点放在那些可以变成不对称的化学上。这样，多环产物将以单一对映体的形式产生。选择用于合成的目标来自广泛的天然结构，包括萜类、生物碱和其他包含碳环和杂环框架的复杂体系。有了这个奖，有机和高分子化学计划(有机合成)支持俄勒冈州立大学的詹姆斯·D·怀特教授的研究。怀特教授参与了天然产物的全合成，即从某些自然来源中分离出来的特定分子通过一系列化学反应精确地复制出来。在这项工作中所采用的战略和战术决定了在实验室环境中制备这些分子的效率，这通常将决定一种特定物质是否可以大规模生产用于制药或其他用途。

This project explores new strategies and methods for the total synthesis of a variety of structural types of natural products. The emphasis of the project is on cycloaddition chemistry, and the focus is placed upon those that can be rendered asymmetric. In this way, polycyclic products will be produced as single enantiomers. The targets selected for synthesis are taken from the broad palette of naturally occurring structures that includes terpene, alkaloids, and other complex systems containing both carbocyclic and heterocyclic frameworks.With this Award, the Organic and Macromolecular Chemistry Program (Organic Synthesis) supports the research of Professor James D. White of Oregon State University. Professor White is involved in the total synthesis of natural products, wherein specific molecules that have been isolated from some natural source are replicated in exact detail through a series of chemical reactions. The strategies and tactics that one employs in this endeavor determine the efficiency with which these molecules are prepared in a laboratory setting, and this often will determine whether or not a particular substance can be mass-produced for pharmaceutical or other use.