Neurohormonal Regulation of Physiological Function

生理功能的神经激素调节

• 批准号: 0076615
• 负责人: Ruthann Nichols
• 金额: $ 33万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2004-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0076615&HistoricalAwards=false
• 关键词: Neurohormonal; Regulation; Physiological; Function

This research will contribute to learning how a novel allatostatin (AST) peptide affects heart rate. Studies will be conducted to determine which part of the peptide is required for its effect, how the peptide interacts with other molecules to cause its activity, and where and when the peptide is present in the brain and gut in order to understand how AST acts. Environmental and physiological factors influence the brain to release peptide hormones that affect activities essential to the development and well being of an animal. The role of peptide hormones as messengers and modulators of critical functions makes it important to delineate the mechanisms by which they act. Understanding how a peptide acts and where it exists in an animal provides important basic science that can lead to applied science applications.

这项研究将有助于了解一种新的allatostatin（AST）肽如何影响心率。 将进行研究以确定肽的哪一部分是其作用所必需的，肽如何与其他分子相互作用以引起其活性，以及肽何时何地存在于大脑和肠道中，以了解AST如何起作用。环境和生理因素影响大脑释放肽激素，影响动物发育和健康所必需的活动。 肽类激素作为信使和重要功能的调节剂的作用使得描述它们的作用机制变得重要。 了解肽如何作用以及它在动物中的存在位置提供了重要的基础科学，可以导致应用科学应用。