Synthesis of Novel Carbohydrate-Based Materials as Scaffolds for Unique Structural Motifs

合成新型碳水化合物基材料作为独特结构图案的支架

• 批准号: 0078756
• 负责人: Jacquelyn Gervay-Hague
• 金额: $ 31.1万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2001-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0078756&HistoricalAwards=false
• 关键词: Synthesis; Novel; Carbohydrate; Based; Materials

The focus of this research is the preparation of NeuAc homooligomers and NeuAc/alpha-amino acid conjugates to form compounds with unique secondary structures. Amide-linked oligomers will be conjugated with biotin for biological screening and to polymerizable lipids for protein screening. Oligomers will be conjugated to form tertiary structures or coiled coils. Circular dichroism and inverse detected nuclear magnetic resonance techniques will be used to elucidate structure of the resulting polysialoamides.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Jacquelyn Gervay-Hague of the Department of Chemistry at the University of Arizona. Professor Gervay-Hague will focus her work on the synthesis and characterization of new carbohydrate-based materials with stable secondary structures in aqueous solution. This is the first step toward engineering artificial proteins. These materials have potential impact for use in drug delivery, as biosensors, as affinity materials and as chemical catalysts. Further, the project provides a diverse and multidimensional training environment for human resource development.

本研究的重点是制备NeuAc均聚物和NeuAc/α-氨基酸缀合物，以形成具有独特二级结构的化合物。 酰胺连接的低聚物将与生物素缀合用于生物筛选，并与可聚合脂质缀合用于蛋白质筛选。 低聚物将缀合以形成三级结构或卷曲螺旋。 圆二色谱和反向检测核磁共振技术将用于阐明所得聚唾液酸酰胺的结构。有了这个更新奖项，有机和大分子化学计划支持亚利桑那大学化学系的Jacquelyn Gervay-Hague博士的研究。 Gervay-Hague教授将专注于在水溶液中具有稳定二级结构的新型碳水化合物材料的合成和表征。 这是工程化人工蛋白质的第一步。 这些材料具有潜在的影响，用于药物输送，作为生物传感器，作为亲和材料和作为化学催化剂。 此外，该项目为人力资源开发提供了一个多样化和多层面的培训环境。