Synthesis of Novel Materials Utilizing Sialic Acid Derivatives as Peptide Equivalents

本研究的重点有三个方面。首先，将开发一种新的材料的制备方法，该材料由氨基酸与聚合唾液酸低聚物的羧基和氨基末端缩合而成。第二，将开发固体载体方法，以制备一类以唾液酸为多肽等价物的新型材料。第三，将使用核磁共振波谱和分子模拟来研究这些材料的溶液相构象。教育活动包括一项旨在发展有机化学中基于发现的学习方法的化学教育计划。通过这一职业奖项，合成有机项目支持亚利桑那大学化学系Jacqueline Gervay博士的研究和教育活动。Gervay教授将把她的研究重点放在开发合成新材料的路线上，这种材料将有选择地取代重要的生物识别过程。合成的目标包括基于唾液酸的低聚化合物，这些化合物将破坏蛋白质-蛋白质之间的相互作用，包括螺旋和静电相互作用。Gervay博士的教育活动包括一个化学教育项目，旨在发展有机化学中基于发现的学习方法。

The focus of this research is threefold. First, methods will be developed for the preparation of a new class of materials derived from condensation of amino acids with both carboxy and amino termini of polymeric sialic acid oligomers. Second, solid support methods will be developed for the preparation of a new class of materials utilizing sialic acid as peptide equivalents. Third, the solution phase conformation of these materials will be examined using nuclear magnetic resonance (NMR) spectroscopy and molecular modeling. Educational activities involve a program in chemical education directed to developing discovery based learning methods in organic chemistry. With this CAREER award, the Synthetic Organic Program supports the research and educational activities of Dr. Jacqueline Gervay of the Department of Chemistry at the University of Arizona. Professor Gervay will focus her research efforts on developing synthetic routes to novel materials that will selectively replace important biological recognition processes. The synthetic targets include sialic acid based oligomeric compounds that will disrupt protein-protein interactions involving both helical and electrostatic interactions. Dr. Gervay's educational activities involve a program in chemical education directed to developing discovery based learning methods in organic chemistry.