Design and Synthesis of Molecular Scaffolds with Defined Ligand Arrays

具有明确配体阵列的分子支架的设计与合成

• 批准号: 0518010
• 负责人: Jacquelyn Gervay-Hague
• 金额: --
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0518010&HistoricalAwards=false
• 关键词: Design; Synthesis; Molecular; Scaffolds; Defined

The Organic and Macromolecular Chemistry Program supports Professor Jacquelyn Gervay-Hague at the University of California-Davis whose research will take a dual approach to the design and synthesis of molecular scaffolds with defined ligand arrays. Rationally designed constructs will be decorated with polyvalent ligand displays that will be structurally defined using common biophysical methods including CD, NH/ND exchange, and computational chemistry. In complementary studies, combinatorial libraries will be generated as molecular probes to establish the design features that are important in the molecular recognition events under study. At a fundamental level, the proposed studies will provide insight into how multivalent interactions translate into macromolecular structure and function. These innovations may lead to the development of new tools for studying biological recognition events and identification of potential candidates for novel chemotherapeutic interventions.The Organic and Macromolecular Chemistry Program supports Professor Jacquelyn Gervay-Hague whose research will extend the research group's investigations of the synthesis and structural characterization of conformationally defined carbohydrate-based ligand materials and structures. Students engaged in the research will develop diverse and multidimensional skills. Organic synthesis (solid-phase and combinatorial techniques), advanced NMR techniques, circular dichroism, and computational chemistry are regularly implemented in Professor Gervay-Hague's research endeavors. Students and postdoctoral researchers will also receive extensive training in biochemistry, since the targeted materials are designed with biological applications in mind. These combined skills will provide a strong foundation for careers in the pharmaceutical industry and in research-oriented academic institutions.

有机和大分子化学项目支持加州大学戴维斯分校的Jacquelyn Gervay-Hague教授，他的研究将采用双重方法来设计和合成具有确定配体阵列的分子支架。合理设计的结构将用多价配体显示装饰，这些配体将使用常见的生物物理方法（包括CD， NH/ND交换和计算化学）进行结构定义。在互补研究中，组合文库将作为分子探针生成，以建立在所研究的分子识别事件中重要的设计特征。在基本层面上，提出的研究将提供深入了解多价相互作用如何转化为大分子结构和功能。这些创新可能会导致开发新的工具来研究生物识别事件和确定新的化疗干预的潜在候选者。有机和大分子化学项目支持Jacquelyn Gervay-Hague教授，他的研究将扩展研究小组对构象定义的碳水化合物基配体材料和结构的合成和结构表征的研究。从事研究的学生将发展多样化和多维的技能。有机合成（固相和组合技术），先进的核磁共振技术，圆二色性和计算化学在Gervay-Hague教授的研究工作中定期实施。学生和博士后研究人员也将接受广泛的生物化学培训，因为目标材料的设计考虑到了生物应用。这些综合技能将为制药行业和研究型学术机构的职业生涯提供坚实的基础。