Chiral 8,8'- Disubstituted 1,1'- Binaphthyls in Asymmetric Catalysis

该项目的目标是开发有效和通用的不对称Heck反应催化剂。在这个方向上的工作集中在使用精致的BINAP-膦配体，其中在无环底物中表现出显著的对映选择性。建议了这类膦配体在不对称环化反应中可能的过渡态，以帮助合理设计额外的催化剂。还将研究在生物碱合成中的应用以及固体负载钯配合物在不对称催化中的应用。凭借这一奖项，有机与高分子计划的有机合成计划支持堪萨斯州立大学的杜伊·H·华教授的研究。华教授研究了一种被称为Heck反应的特殊类型的反应，它在药物分子的合成中有许多潜在的应用。然而，这种反应的一个弱点是它无法控制分子组装的三维方面。华教授已经在这个方向上取得了长足的进步，并将在有机合成计划的支持下继续这样做。

This project has as its goal the development of effective and general catalysts for the asymmetric Heck reaction. Work in this direction focuses on the use of elaborated BINAP-phosphine ligands where significant enantioselectivity was demonstrated in an acyclic substrate. Possible transition states of this class of phosphine ligand in asymmetric cyclization were suggested to aid in the rational design of additional catalysts. Application in alkaloid synthesis and the use of solid supported palladium complexes in asymmetric catalysis will also be investigated.With this Award, the Organic and Macromolecular Program's Organic Synthesis Program supports the research of Professor Duy H. Hua of Kansas State University. Professor Hua studies a particular type of reaction known as the Heck reaction, which has many potential applications in the synthesis of pharmaceutical molecules. However, one weakness of this reaction is its inability to govern the three-dimensional aspect of molecular assembly. Professor Hua has made strides in this direction, and will continue to do so with the support of the Organic Synthesis Program.