Investigation of Reactive Intermediates and Inner Phase Reactions Inside Molecular Container Compounds

分子容器化合物内部反应中间体和内相反应的研究

• 批准号: 0075749
• 负责人: Duy Hua
• 金额: $ 29.89万
• 依托单位: Kansas State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0075749&HistoricalAwards=false
• 关键词: Investigation; Reactive; Intermediates; Inner; Phase

This project has the long term objective to apply molecular container compounds in areas such as the characterization of reactive intermediates and in catalysis. Two highly strained cyclic allenes and various intermediates in the naphthylcarbene rearrangement will be generated and spectroscopically characterized in the inner phase of hemicarcerands, and their thermochemistry will be investigated. These species are important to structural theory in organic chemistry. In addition, a new approach for the stabilization of reactive intermediates will be developed. This approach involves the covalent bonding of a precursor molecule on the inside of a hemicarcerand, whereupon generation of a reactive intermediate from this precursor takes place to the exclusion of other reactive species. Quenching of the intermediate is thus prevented.With this award, the Organic and Macromolecular Chemistry Program's Organic Dynamics Program supports the research of Professor Ralf Warmuth of Kansas State University. Professor Warmuth is pursuing an area of physical organic chemistry wherein chemical species that are implicated as intermediates in reaction processes are created and observed. These species are referred to as reactive intermediates, and are normally so short-lived that direct observation is difficult. By forming these intermediates in a protective shell, Professor Warmuth will be able to extend the lifetimes of these elusive entities, making their observation more feasible.

该项目的长期目标是将分子容器化合物应用于反应中间体的表征和催化等领域。 将在半癌的内相中生成萘基碳烯重排中的两种高张力环状丙二烯和各种中间体，并对其进行光谱表征，并研究它们的热化学。 这些物种对于有机化学的结构理论很重要。 此外，还将开发一种稳定反应中间体的新方法。 这种方法涉及前体分子在半癌细胞内部的共价键合，随后从该前体产生反应性中间体，从而排除其他反应性物质。 从而防止了中间体的猝灭。有机和高分子化学项目的有机动力学项目通过该奖项支持堪萨斯州立大学 Ralf Warmuth 教授的研究。 Warmuth 教授正在研究物理有机化学领域，其中创建并观察作为反应过程中间体的化学物质。 这些物质被称为反应中间体，通常寿命很短，很难直接观察。 通过在保护壳中形成这些中间体，沃姆斯教授将能够延长这些难以捉摸的实体的寿命，使他们的观察变得更加可行。