Integration of Capillary Column Gas Chromatography into Project-Oriented Laboratories

将毛细管柱气相色谱仪集成到面向项目的实验室

• 批准号: 0087736
• 负责人: Steven Drew
• 金额: $ 3.51万
• 依托单位: Carleton College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0087736&HistoricalAwards=false
• 关键词: Integration; Capillary; Column; Gas; Chromatography

Chemistry (12) Capillary column gas chromatography (GC) is integrated into several courses that offer multi-week, collaborative, project-oriented laboratory experiences, using experiments which are adapted from standard literature. The Chemistry Department currently offers many of these types of laboratory experiences to students, but feel the addition of several capillary column GC's would greatly enhance the range of projects that could be offered. The Department greatly values multi-week, collaborative, project-oriented laboratories because the skills students develop, such as working as a member of a team, designing experiments, and evaluating data, are central to being a scientist. In addition, offering multi-week projects, which closely parallel a true research experience, inspires more students to seek out undergraduate research experiences. Capillary column GC is a flexible, fast, and quantitative tool that can support many types of projects in introductory, environmental, and organic chemistry. The GC instruments have temperature programming capabilities and are equipped with two detectors, two columns, and an integrator for each instrument. The majority of the GC instruments have flame ionization detectors; however, two of the instruments are each equipped with an electron capture detector. The addition of two electron capture detectors allows two of the GC instruments to support project-oriented laboratories in environmental chemistry courses where the selective detection of halogenated and nitro-substituted compounds, a typical motif for many pesticides and herbicides, are crucial. The majority of the capillary column GC usage occurs in sophomore organic chemistry laboratories where there has been a shift in curricular focus to offering all project-oriented laboratory experiences. Some examples of projects to be offered include the examination of competitive reaction pathways in the dehydration reaction of an alcohol, a study of structure/reactivity relationships in the Diels-Alder reaction, and the examination of the enantioselective reduction of an acylnaphthalene derivative. Introductory and environmental chemistry courses at Carleton offer at least one multi-week, project oriented laboratory experience. During this period students usually pick from a menu of possible projects that a team can undertake. In introductory chemistry three projects take advantage of the new capillary column GC's. These projects include an examination of intermolecular forces in several liquids, the investigation of a simulated forensic arson sample, and the investigation of the volatility of fluorinated metal-acetylacetonate complexes. In environmental chemistry a project would call for a student group to examine the distribution of a herbicide in either soil or water in the immediate region around the campus. An additional project is also used to examine pesticides and herbicides in commercially grown fruits and vegetables.

化学（12）毛细管柱气相色谱（GC）被整合到几个课程，提供多周，协作，以项目为导向的实验室经验，使用从标准文献改编的实验。化学系目前为学生提供许多此类实验室经验，但认为增加几个毛细管柱GC将大大提高可以提供的项目范围。该部门非常重视多周，协作，以项目为导向的实验室，因为学生发展的技能，如作为一个团队的一员，设计实验和评估数据，是中央成为一名科学家。此外，提供多周的项目，这密切平行的真正的研究经验，激励更多的学生寻求本科研究经验。毛细管柱GC是一种灵活，快速和定量的工具，可以支持介绍，环境和有机化学的许多类型的项目。GC仪器具有温度编程能力，每个仪器配备有两个检测器、两个色谱柱和一个积分器。大多数GC仪器都有火焰离子化检测器;然而，其中两台仪器都配备了电子捕获检测器。添加两个电子捕获检测器允许两个GC仪器支持环境化学课程中以项目为导向的实验室，其中卤代和硝基取代化合物的选择性检测是至关重要的，这是许多杀虫剂和除草剂的典型主题。大多数毛细管柱GC的使用发生在大二的有机化学实验室，那里的课程重点已经转移到提供所有以项目为导向的实验室经验。提供的一些项目的例子包括在醇的脱水反应中的竞争性反应途径的检查，在Diels-Alder反应中的结构/反应性关系的研究，以及酰基萘衍生物的对映选择性还原的检查。卡尔顿的入门和环境化学课程提供至少一个多周的项目导向实验室经验。在此期间，学生通常从一个团队可以承担的可能项目菜单中选择。在介绍化学三个项目利用新的毛细管柱GC的。这些项目包括在几种液体中的分子间力的检查，模拟法医纵火样品的调查，和氟化金属乙酰丙酮络合物的挥发性的调查。在环境化学中，一个项目将要求一个学生小组检查校园周围区域土壤或水中除草剂的分布。另外一个项目还用于检查商业种植的水果和蔬菜中的杀虫剂和除草剂。